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    Pop1 POP1 homolog, ribonuclease P/MRP subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315045, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pop1provided by RGD
    Official Full Name
    POP1 homolog, ribonuclease P/MRP subunitprovided by RGD
    Primary source
    RGD:1308609
    See related
    EnsemblRapid:ENSRNOG00000005243 AllianceGenome:RGD:1308609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease P activity. Predicted to be involved in tRNA 5'-leader removal and tRNA decay. Predicted to be located in nucleolus. Predicted to be part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Human ortholog(s) of this gene implicated in anauxetic dysplasia 2. Orthologous to human POP1 (POP1 homolog, ribonuclease P/MRP subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 44.9), Thymus (RPKM 25.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pop1 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (67590502..67618187)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (65705348..65733143)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (73270403..73298209)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene glutamate-rich 5 Neighboring gene reactive intermediate imine deaminase A homolog Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120093631 Neighboring gene NIPA-like domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. hPop1: an autoantigenic protein subunit shared by the human RNase P and RNase MRP ribonucleoproteins. Lygerou Z, et al. EMBO J, 1996 Nov 1. PMID 8918471, Free PMC Article
    2. Unexpected diversity of RNase P, an ancient tRNA processing enzyme: challenges and prospects. Lai LB, et al. FEBS Lett, 2010 Jan 21. PMID 19931535, Free PMC Article
    3. Differential association of protein subunits with the human RNase MRP and RNase P complexes. Welting TJ, et al. RNA, 2006 Jul. PMID 16723659, Free PMC Article
    4. Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. Wu J, et al. Cell, 2018 Nov 15. PMID 30454648
    5. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ribonuclease P RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ribonuclease P activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in tRNA 5'-leader removal ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of multimeric ribonuclease P complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleolar ribonuclease P complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleolar ribonuclease P complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonuclease MRP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonuclease MRP complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribonucleases P/MRP protein subunit POP1
    Names
    processing of precursor 1, ribonuclease P/MRP subunit
    NP_001124022.1
    XP_006241605.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130550.1 → NP_001124022.1  ribonucleases P/MRP protein subunit POP1 isoform 2

      See identical proteins and their annotated locations for NP_001124022.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A6HR04, D4AE75
      Related
      ENSRNOP00000007190.5, ENSRNOT00000007190.8
      Conserved Domains (2) summary
      pfam06978
      Location:106 → 256
      POP1; Ribonucleases P/MRP protein subunit POP1
      pfam08170
      Location:647 → 736
      POPLD; POPLD (NUC188) domain

    2. NM_001434609.1 → NP_001421538.1  ribonucleases P/MRP protein subunit POP1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2K4R5, A6HR05

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      67590502..67618187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241543.5 → XP_006241605.1  ribonucleases P/MRP protein subunit POP1 isoform X1

      Related
      ENSRNOP00000073143.1, ENSRNOT00000077730.3
      Conserved Domains (2) summary
      pfam06978
      Location:106 → 256
      POP1; Ribonucleases P/MRP protein subunit POP1
      pfam08170
      Location:617 → 706
      POPLD; POPLD (NUC188) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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