Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prkag1provided by RGD
Official Full Name: protein kinase AMP-activated non-catalytic subunit gamma 1provided by RGD
Primary source: RGD:3388
See related: EnsemblRapid:ENSRNOG00000070180 AllianceGenome:RGD:3388
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Prkaac; Prkga1
Summary: Enables adenyl ribonucleotide binding activity; protein kinase binding activity; and protein kinase regulator activity. Contributes to AMP-activated protein kinase activity. Involved in regulation of catalytic activity. Part of nucleotide-activated protein kinase complex. Orthologous to human PRKAG1 (protein kinase AMP-activated non-catalytic subunit gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 302.4), Adrenal (RPKM 267.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (131842058..131859484, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (129963105..129980532, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (140489499..140506925, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

S-nitrosylation of AMPKgamma impairs coronary collateral circulation and disrupts VSMC reprogramming.
Title: S-nitrosylation of AMPKγ impairs coronary collateral circulation and disrupts VSMC reprogramming.
Adiponectin enhances the bioenergetics of cardiac myocytes via an AMPK- and succinate dehydrogenase-dependent mechanism.
Title: Adiponectin enhances the bioenergetics of cardiac myocytes via an AMPK- and succinate dehydrogenase-dependent mechanism.
Studies determine the three-dimensional reconstruction and subunit organization of the full-length rat AMPK (alpha1beta1gamma1) through single-particle electron
Title: Structural insights into the architecture and allostery of full-length AMP-activated protein kinase.
Dietary energy restriction modulates the activity of AMP-activated protein kinase in mammary carcinomas, mammary gland, and liver.
Title: Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver.
In pancreatic beta cells, expression of a constitutively active form of Akt increases mTOR activity and prevents apoptosis upon AMP-activated protein kinase activation.
Title: Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR.
Leptin and insulin deficiencies in diabetes lead to increased hypothalamic AMP activated protein kinase which contributes to the development of diabetic hyperphagia.
Title: Enhanced hypothalamic AMP-activated protein kinase activity contributes to hyperphagia in diabetic rats.
results indicate that ischemia activates catalytic alpha1 and alpha2 isoforms similarly in gamma1 and gamma2 isoform-containing AMPK complexes and that gamma1-isoform complexes account for most of the AMPK activity in the ischemic heart
Title: Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124519 (e-PCR)
- UniSTS:161341

RH130668 (e-PCR)
- UniSTS:213952

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP binding	IDA Inferred from Direct Assay more info	PubMed
enables AMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables AMP binding	IDA Inferred from Direct Assay more info	PubMed
enables AMP binding	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to AMP-activated protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to AMP-activated protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to glucose starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to nutrient levels	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of carbon utilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of catalytic activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of glycolytic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
part_of nucleotide-activated protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleotide-activated protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of nucleotide-activated protein kinase complex	IEA Inferred from Electronic Annotation more info
part_of nucleotide-activated protein kinase complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 5'-AMP-activated protein kinase subunit gamma-1

Names: AMP-activated protein kinase, noncatalytic gamma-1 subunit; AMPK gamma-1 chain; AMPK gamma1; AMPK subunit gamma-1; AMPKg; Protein kinase AMP-activated gamma; protein kinase, AMP-activated, gamma 1 non-catalytic subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013010.2 → NP_037142.1 5'-AMP-activated protein kinase subunit gamma-1

See identical proteins and their annotated locations for NP_037142.1

Status: PROVISIONAL

Source sequence(s)

BC097940

UniProtKB/Swiss-Prot

P80385, Q4QQW6

UniProtKB/TrEMBL

A0A0G2K913

Related

ENSRNOP00000091419.2, ENSRNOT00000105867.2

Conserved Domains (2) summary

cd04618
Location:37 → 173

CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1

cd04641
Location:199 → 322

CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

131842058..131859484 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006257331.5 → XP_006257393.1 5'-AMP-activated protein kinase subunit gamma-1 isoform X1

See identical proteins and their annotated locations for XP_006257393.1

UniProtKB/TrEMBL

A0A8L2R2B3, A6KCB1

Related

ENSRNOP00000070458.2, ENSRNOT00000083354.3

Conserved Domains (2) summary

cd04618
Location:6 → 142

CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1

cd04641
Location:168 → 291

CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase