P3h2 prolyl 3-hydroxylase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: P3h2provided by RGD
Full Name: prolyl 3-hydroxylase 2provided by RGD
Primary source: RGD:1304568
See related: EnsemblRapid:ENSRNOG00000055751 AllianceGenome:RGD:1304568
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Leprel1
Summary: Enables procollagen-proline 3-dioxygenase activity. Involved in collagen metabolic process and peptidyl-proline hydroxylation. Predicted to be located in several cellular components, including Golgi apparatus; basement membrane; and nucleoplasm. Predicted to be active in endoplasmic reticulum. Orthologous to human P3H2 (prolyl 3-hydroxylase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 484.9), Spleen (RPKM 100.7) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (88139086..88280221)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (74634267..74775422)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (78028885..78169746)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P3H2 has preferred substrate sequences among the classes of 3Hyp sites in clade A collagen chains
Title: A role for prolyl 3-hydroxylase 2 in post-translational modification of fibril-forming collagens.

Submit: New GeneRIF Correction

General gene information

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Markers

AU048531 (e-PCR)
- UniSTS:144981

D11Got65 (e-PCR)
- UniSTS:112797

Leprel2 (e-PCR), detects polymorphism
- UniSTS:528049

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-ascorbic acid binding	IEA Inferred from Electronic Annotation more info
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables procollagen-proline 3-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables procollagen-proline 3-dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables procollagen-proline 3-dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables procollagen-proline 3-dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables procollagen-proline 3-dioxygenase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in collagen metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in collagen metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in collagen metabolic process	IEA Inferred from Electronic Annotation more info
involved_in collagen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in collagen metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-proline hydroxylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-proline hydroxylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-proline hydroxylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in basement membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prolyl 3-hydroxylase 2

Names: leprecan-like 1; leprecan-like protein 1

NP_001020798.1

EC 1.14.11.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.