Dnah1 dynein, axonemal, heavy chain 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnah1provided by RGD
Official Full Name: dynein, axonemal, heavy chain 1provided by RGD
Primary source: RGD:621795
See related: EnsemblRapid:ENSRNOG00000026914 AllianceGenome:RGD:621795
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dnahc1; RGD1311110
Summary: Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in sperm axoneme assembly. Predicted to act upstream of or within cilium movement involved in cell motility; epithelial cilium movement involved in extracellular fluid movement; and inner dynein arm assembly. Predicted to be located in axoneme and extracellular region. Predicted to be part of inner dynein arm. Predicted to be active in sperm flagellum. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 37 and spermatogenic failure 18. Orthologous to human DNAH1 (dynein axonemal heavy chain 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 43.4), Lung (RPKM 37.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p16

Exon count:: 79

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (6462419..6523545, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (6455514..6517103, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (7345131..7407009, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables minus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables minus-end-directed microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cilium movement involved in cell motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within inner dynein arm assembly	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in sperm axoneme assembly	ISO Inferred from Sequence Orthology more info
involved_in sperm axoneme assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dynein complex	IEA Inferred from Electronic Annotation more info
part_of inner dynein arm	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
is_active_in sperm flagellum	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dynein axonemal heavy chain 1

Names: axonemal beta dynein heavy chain 1; ciliary dynein heavy chain 1; dynein heavy chain 1, axonemal; dynein, axonemal, heavy polypeptide 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033655.2 → NP_001028827.2 dynein axonemal heavy chain 1

Status: VALIDATED

Source sequence(s)

D26492, JAXUCZ010000016

UniProtKB/Swiss-Prot

Q63164

UniProtKB/TrEMBL

D3ZRN8

Related

ENSRNOP00000059841.3, ENSRNOT00000066508.6

Conserved Domains (4) summary

COG5245
Location:1237 → 3883

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam08393
Location:998 → 1401

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12774
Location:1528 → 1854

AAA_6; Hydrolytic ATP binding site of dynein motor region D1

pfam18199
Location:3944 → 4246

Dynein_C; Dynein heavy chain C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

6462419..6523545 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275052.1 → XP_063131122.1 dynein axonemal heavy chain 1 isoform X4

UniProtKB/Swiss-Prot

Q63164
XM_017599982.3 → XP_017455471.1 dynein axonemal heavy chain 1 isoform X2

UniProtKB/Swiss-Prot

Q63164

UniProtKB/TrEMBL

A0A8I6GJB4
XM_039094184.2 → XP_038950112.1 dynein axonemal heavy chain 1 isoform X1

UniProtKB/Swiss-Prot

Q63164

Conserved Domains (5) summary

COG5245
Location:1237 → 3845

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam08393
Location:998 → 1401

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12774
Location:1509 → 1816

AAA_6; Hydrolytic ATP binding site of dynein motor region D1

pfam12780
Location:2503 → 2761

AAA_8; P-loop containing dynein motor region D4

pfam18199
Location:3906 → 4208

Dynein_C; Dynein heavy chain C-terminal domain
XM_017599983.3 → XP_017455472.1 dynein axonemal heavy chain 1 isoform X3

UniProtKB/Swiss-Prot

Q63164
XM_039094185.2 → XP_038950113.1 dynein axonemal heavy chain 1 isoform X5

UniProtKB/Swiss-Prot

Q63164

Conserved Domains (4) summary

COG5245
Location:1002 → 3648

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam08393
Location:763 → 1166

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12774
Location:1293 → 1619

AAA_6; Hydrolytic ATP binding site of dynein motor region D1

pfam18199
Location:3709 → 4011

Dynein_C; Dynein heavy chain C-terminal domain
XM_039094186.2 → XP_038950114.1 dynein axonemal heavy chain 1 isoform X7

Conserved Domains (4) summary

COG5245
Location:327 → 2973

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam08393
Location:88 → 491

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12774
Location:618 → 944

AAA_6; Hydrolytic ATP binding site of dynein motor region D1

pfam18199
Location:3034 → 3336

Dynein_C; Dynein heavy chain C-terminal domain
XM_008770978.4 → XP_008769200.1 dynein axonemal heavy chain 1 isoform X6

UniProtKB/Swiss-Prot

Q63164

Related

ENSRNOP00000091035.2, ENSRNOT00000114829.2

Conserved Domains (5) summary

pfam03028
Location:3545 → 3972

Dynein_heavy; Dynein heavy chain and region D6 of dynein motor

pfam08393
Location:1001 → 1402

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12777
Location:2816 → 3162

MT; Microtubule-binding stalk of dynein motor

pfam12781
Location:3191 → 3406

AAA_9; ATP-binding dynein motor region D5

cl21455
Location:1528 → 1758

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_017599984.3 → XP_017455473.1 dynein axonemal heavy chain 1 isoform X8