Rbm3 RNA binding motif protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rbm3provided by RGD
Official Full Name: RNA binding motif protein 3provided by RGD
Primary source: RGD:620145
See related: EnsemblRapid:ENSRNOG00000005387 AllianceGenome:RGD:620145
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA binding activity and ribosomal large subunit binding activity. Involved in positive regulation of translation. Located in cytoplasm; dendrite; and nucleus. Part of large ribosomal subunit. Orthologous to human RBM3 (RNA binding motif protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 1338.6), Spleen (RPKM 1167.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (17020863..17024341)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (14348909..14352387)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (15098880..15102344)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RBM3 Ameliorates Acute Brain Injury-induced Inflammation and Oxidative Stress by Stabilizing GAS6 mRNA Through Nrf2 Signaling Pathway.
Title: RBM3 Ameliorates Acute Brain Injury-induced Inflammation and Oxidative Stress by Stabilizing GAS6 mRNA Through Nrf2 Signaling Pathway.
The mRNA-Binding Protein RBM3 Regulates Activity Patterns and Local Synaptic Translation in Cultured Hippocampal Neurons.
Title: The mRNA-Binding Protein RBM3 Regulates Activity Patterns and Local Synaptic Translation in Cultured Hippocampal Neurons.
Overexpression of RBM3 also attenuated muscle atrophy in rat soleus muscle undergoing disuse atrophy. These findings provide direct evidence for a novel role of RBM3 in inducing hypertrophy as well as attenuating atrophy.
Title: Cold shock protein RBM3 attenuates atrophy and induces hypertrophy in skeletal muscle.
This study showed that a 1 degrees C reduction in temperature can induce pleiotropic biochemical changes by upregulating global protein synthesis in neurons.
Title: Cold stress protein RBM3 responds to temperature change in an ultra-sensitive manner in young neurons.
RBM3 expression was increased in astrocytes after spinal cord injury. RBM3 regulated proliferation of astrocytes in vitro.
Title: Spatiotemporal profile and essential role of RBM3 expression after spinal cord injury in adult rats.
RBM3 might play important roles in central nervous system pathophysiology after spinal cord injury
Title: Spatiotemporal pattern of RNA-binding motif protein 3 expression after spinal cord injury in rats.
These results indicate that expression of RBM3 is dynamically regulated in the developing brain and suggest that it contributes to translation-dependent processes underlying proliferation, differentiation, and plasticity.
Title: Developmentally regulated expression of the cold-inducible RNA-binding motif protein 3 in euthermic rat brain.
Aa cold-shock response may be part of a compensatory mechanism in muscles undergoing atrophy to preserve remaining muscle mass. RBM3, which was induced most highly in atrophic muscle from old rats, may be a therapeutic target to prevent muscle loss.
Title: Identification of cold-shock protein RBM3 as a possible regulator of skeletal muscle size through expression profiling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_3075-3076:991936711:1 (e-PCR)
- UniSTS:230986

MARC_3075-3076:996678948:1 (e-PCR)
- UniSTS:230986

RH127858 (e-PCR)
- UniSTS:211168

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosomal large subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal large subunit binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to cold	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within translation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
part_of large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA-binding protein 3

Names: RNA binding motif (RNP1, RRM) protein 3; putative RNA-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053696.1 → NP_446148.1 RNA-binding protein 3

See identical proteins and their annotated locations for NP_446148.1

Status: VALIDATED

Source sequence(s)

AF355190, CA340698, DN933310, DY319481

UniProtKB/Swiss-Prot

Q925G0

UniProtKB/TrEMBL

A6KP47, G3V6P6

Related

ENSRNOP00000007367.4, ENSRNOT00000007367.8

Conserved Domains (1) summary

cd12449
Location:6 → 85

RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

17020863..17024341

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256694.3 → XP_006256756.1 RNA-binding protein 3 isoform X1

See identical proteins and their annotated locations for XP_006256756.1

UniProtKB/Swiss-Prot

Q925G0

UniProtKB/TrEMBL

A6KP47, G3V6P6

Conserved Domains (1) summary

cd12449
Location:6 → 85

RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins
XM_006256695.3 → XP_006256757.1 RNA-binding protein 3 isoform X2

See identical proteins and their annotated locations for XP_006256757.1

UniProtKB/Swiss-Prot

Q925G0

Conserved Domains (1) summary

cd12449
Location:6 → 85

RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins
XM_006256696.3 → XP_006256758.1 RNA-binding protein 3 isoform X2

See identical proteins and their annotated locations for XP_006256758.1

UniProtKB/Swiss-Prot

Q925G0

Conserved Domains (1) summary

cd12449
Location:6 → 85

RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins
XM_063279735.1 → XP_063135805.1 RNA-binding protein 3 isoform X3
XM_063279736.1 → XP_063135806.1 RNA-binding protein 3 isoform X3