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    Il1rapl2 interleukin 1 receptor accessory protein-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300913, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Il1rapl2provided by RGD
    Official Full Name
    interleukin 1 receptor accessory protein-like 2provided by RGD
    Primary source
    RGD:1561761
    See related
    EnsemblRapid:ENSRNOG00000062221 AllianceGenome:RGD:1561761
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561761
    Summary
    Predicted to enable hydrolase activity and interleukin-1, type II, blocking receptor activity. Predicted to be involved in cell surface receptor signaling pathway and regulation of presynapse assembly. Predicted to be located in membrane. Predicted to be active in cell surface; glutamatergic synapse; and plasma membrane. Orthologous to human IL1RAPL2 (interleukin 1 receptor accessory protein like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 31.6) and Brain (RPKM 18.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Il1rapl2 in Genome Data Viewer
    Location:
    Xq32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (105547403..107080369)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (100961509..102271753)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (108287034..109851075)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene peptidase, mitochondrial processing subunit beta, pseudogene 1 Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 3 Neighboring gene LSM12 homolog, pseudogene 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 22 Neighboring gene ubiquitin-like protein FUBI Neighboring gene testis expressed 13A Neighboring gene U6 spliceosomal RNA Neighboring gene zinc finger protein ZPR1 pseudogene Neighboring gene zinc finger CCCH domain-containing protein 14-like Neighboring gene large ribosomal subunit protein eL18-like Neighboring gene Nik related kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPδ and RhoGAP2. Valnegri P, et al. Hum Mol Genet, 2011 Dec 15. PMID 21926414, Free PMC Article
    2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-1, type II, blocking receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    X-linked interleukin-1 receptor accessory protein-like 2
    NP_001159814.1
    XP_063135954.1
    XP_063135955.1
    XP_063135956.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166342.3 → NP_001159814.1  X-linked interleukin-1 receptor accessory protein-like 2 precursor

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A1W2Q6G2, A6KNW2
      Related
      ENSRNOP00000076241.1, ENSRNOT00000093348.3
      Conserved Domains (5) summary
      cd00096
      Location:261 → 344
      Ig; Immunoglobulin domain
      cd05757
      Location:146 → 237
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05896
      Location:32 → 133
      Ig1_IL1RAPL-1_like; First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1)
      smart00255
      Location:401 → 559
      TIR; Toll - interleukin 1 - resistance
      smart00410
      Location:250 → 347
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      105547403..107080369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279885.1 → XP_063135955.1  X-linked interleukin-1 receptor accessory protein-like 2 isoform X1

      UniProtKB/TrEMBL
      A0A1W2Q6G2, A6KNW2

    2. XM_063279884.1 → XP_063135954.1  X-linked interleukin-1 receptor accessory protein-like 2 isoform X1

      UniProtKB/TrEMBL
      A0A1W2Q6G2, A6KNW2

    3. XM_063279886.1 → XP_063135956.1  X-linked interleukin-1 receptor accessory protein-like 2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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