Adam1a ADAM metallopeptidase domain 1a [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adam1aprovided by RGD
Official Full Name: ADAM metallopeptidase domain 1aprovided by RGD
Primary source: RGD:621467
See related: EnsemblRapid:ENSRNOG00000001347 AllianceGenome:RGD:621467
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Adam1; PH-30a
Summary: Predicted to enable metalloendopeptidase activity. Involved in male gonad development. Predicted to be located in membrane raft. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. Orthologous to human ADAM1A (ADAM metallopeptidase domain 1A (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 267.9), Heart (RPKM 181.0) and 9 other tissues See more
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Genomic context

Location:: 12q16

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (40674460..40680988)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (35017433..35020300)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (40533731..40536632)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IBA Inferred from Biological aspect of Ancestor more info
involved_in binding of sperm to zona pellucida	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IBA Inferred from Biological aspect of Ancestor more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in sperm head plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 1

Names: ADAM 1; PH-30 alpha; a disintegrin and metallopeptidase domain 1a; a disintegrin and metalloprotease domain 1 (fertilin alpha); a disintegrin and metalloproteinase domain 1 (fertilin alpha); fertilin alpha; fertilin subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020078.1 → NP_064463.1 disintegrin and metalloproteinase domain-containing protein 1 precursor

See identical proteins and their annotated locations for NP_064463.1

Status: PROVISIONAL

Source sequence(s)

Y08616

UniProtKB/Swiss-Prot

P70505

Related

ENSRNOP00000081520.1, ENSRNOT00000001818.7

Conserved Domains (4) summary

smart00050
Location:450 → 522

DISIN; Homologues of snake disintegrins

smart00608
Location:524 → 660

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:238 → 432

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:79 → 194

Pep_M12B_propep; Reprolysin family propeptide