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    Pwwp3a PWWP domain containing 3A, DNA repair factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362838, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pwwp3aprovided by RGD
    Official Full Name
    PWWP domain containing 3A, DNA repair factorprovided by RGD
    Primary source
    RGD:1308340
    See related
    EnsemblRapid:ENSRNOG00000024549 AllianceGenome:RGD:1308340
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mum1
    Summary
    Predicted to enable nucleosome binding activity. Predicted to be involved in DNA repair and chromatin organization. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human PWWP3A (PWWP domain containing 3A, DNA repair factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 226.5), Thymus (RPKM 84.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pwwp3a in Genome Data Viewer
    Location:
    7q11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10115865..10132696, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9465180..9482053, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12331288..12348263, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase core subunit S7 Neighboring gene transfer RNA asparagine (anticodon GUU) 8 Neighboring gene transfer RNA phenylalanine (anticodon GAA) 3 Neighboring gene large ribosomal subunit protein eL33-like Neighboring gene ephrin A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1. Huen MS, et al. Mol Cell, 2010 Mar 26. PMID 20347427, Free PMC Article
    2. Double-strand break repair: 53BP1 comes into focus. Panier S, et al. Nat Rev Mol Cell Biol, 2014 Jan. PMID 24326623
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    PWWP domain-containing DNA repair factor 3A
    Names
    MUM-1
    PWWP domain-containing protein MUM1
    melanoma associated antigen (mutated) 1
    melanoma ubiquitous mutated protein
    mutated melanoma-associated antigen 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108736.2 → NP_001102206.2  PWWP domain-containing DNA repair factor 3A

      Status: PROVISIONAL

      Source sequence(s)
      CB784307, CK597826, CK603499, CK839769, CO383806, CV126168
      UniProtKB/TrEMBL
      A0A8I5ZQH5, A0A8L2QRY6
      Conserved Domains (2) summary
      cd06080
      Location:396 → 475
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...
      pfam03546
      Location:73 → 360
      Treacle; Treacher Collins syndrome protein Treacle

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10115865..10132696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240973.5 → XP_006241035.1  PWWP domain-containing DNA repair factor 3A isoform X1

      See identical proteins and their annotated locations for XP_006241035.1

      UniProtKB/Swiss-Prot
      B1H224
      UniProtKB/TrEMBL
      A0A8I5ZQH5
      Related
      ENSRNOP00000057438.4, ENSRNOT00000060708.4
      Conserved Domains (1) summary
      cd06080
      Location:397 → 487
      PWWP_MUM1-like; PWWP domain found in mutated melanoma-associated antigen 1 (MUM-1) and similar proteins

    2. XM_039079406.2 → XP_038935334.1  PWWP domain-containing DNA repair factor 3A isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQH5, A0A8L2QRY6
      Conserved Domains (2) summary
      cd06080
      Location:396 → 475
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...
      pfam03546
      Location:73 → 360
      Treacle; Treacher Collins syndrome protein Treacle

    3. XM_006240974.5 → XP_006241036.1  PWWP domain-containing DNA repair factor 3A isoform X1

      See identical proteins and their annotated locations for XP_006241036.1

      UniProtKB/Swiss-Prot
      B1H224
      UniProtKB/TrEMBL
      A0A8I5ZQH5
      Conserved Domains (1) summary
      cd06080
      Location:397 → 487
      PWWP_MUM1-like; PWWP domain found in mutated melanoma-associated antigen 1 (MUM-1) and similar proteins

    4. XM_063263746.1 → XP_063119816.1  PWWP domain-containing DNA repair factor 3A isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQH5, A0A8L2QRY6

    5. XM_006240975.5 → XP_006241037.1  PWWP domain-containing DNA repair factor 3A isoform X1

      See identical proteins and their annotated locations for XP_006241037.1

      UniProtKB/Swiss-Prot
      B1H224
      UniProtKB/TrEMBL
      A0A8I5ZQH5
      Conserved Domains (1) summary
      cd06080
      Location:397 → 487
      PWWP_MUM1-like; PWWP domain found in mutated melanoma-associated antigen 1 (MUM-1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1H224.1 GenPept UniProtKB/Swiss-Prot:B1H224

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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