Trmt10c tRNA methyltransferase 10C, mitochondrial RNase P subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trmt10cprovided by RGD
Official Full Name: tRNA methyltransferase 10C, mitochondrial RNase P subunitprovided by RGD
Primary source: RGD:1306333
See related: EnsemblRapid:ENSRNOG00000039567 AllianceGenome:RGD:1306333
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rg9mtd1
Summary: Predicted to enable identical protein binding activity; tRNA binding activity; and tRNA methyltransferase activity. Predicted to be involved in RNA processing and positive regulation of mitochondrial translation. Predicted to be located in mitochondrial nucleoid. Predicted to be part of mitochondrial ribonuclease P complex and tRNA methyltransferase complex. Predicted to be active in mitochondrion and nucleoplasm. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 30. Orthologous to human TRMT10C (tRNA methyltransferase 10C, mitochondrial RNase P subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 135.5), Adrenal (RPKM 114.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (58053455..58058533)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (44584388..44589466)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (47047342..47052420)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables tRNA (adenine(9)-N1)-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables tRNA (guanosine(9)-N1)-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info
enables tRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mRNA processing	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial RNA 5'-end processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial RNA 5'-end processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial tRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial tRNA 5'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial tRNA 5'-end processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial tRNA 5'-end processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial tRNA methylation	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial tRNA processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial tRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mitochondrial translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial translation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	ISS Inferred from Sequence or Structural Similarity more info
part_of mitochondrial ribonuclease P complex	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of tRNA methyltransferase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tRNA methyltransferase 10 homolog C

Names: RNA (guanine-9-) methyltransferase domain containing 1; RNA (guanine-9-)-methyltransferase domain-containing protein 1; mRNA methyladenosine-N(1)-methyltransferase; mitochondrial RNase P protein 1; mitochondrial ribonuclease P protein 1; tRNA (adenine(9)-N(1))-methyltransferase; tRNA (guanine(9)-N(1))-methyltransferase

NP_001008338.1

EC 2.1.1.218

EC 2.1.1.221

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.