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    Vezt vezatin, adherens junctions transmembrane protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299738, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Veztprovided by RGD
    Official Full Name
    vezatin, adherens junctions transmembrane proteinprovided by RGD
    Primary source
    RGD:1359117
    See related
    EnsemblRapid:ENSRNOG00000006514 AllianceGenome:RGD:1359117
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable myosin binding activity. Predicted to be involved in cell-cell adhesion and synapse maturation. Predicted to act upstream of or within chordate embryonic development. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of stereocilia ankle link complex. Predicted to be active in glutamatergic synapse; plasma membrane; and postsynapse. Orthologous to human VEZT (vezatin, adherens junctions transmembrane protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 146.9), Brain (RPKM 124.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vezt in Genome Data Viewer
    Location:
    7q13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (30399208..30484429, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (28512214..28597429, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (34888487..34951712, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 Neighboring gene ubiquitin specific peptidase 44 Neighboring gene methionyl aminopeptidase 2 Neighboring gene uncharacterized LOC120093556 Neighboring gene microRNA 331 Neighboring gene FYVE, RhoGEF and PH domain containing 6 Neighboring gene nuclear receptor subfamily 2, group C, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex. Küssel-Andermann P, et al. EMBO J, 2000 Nov 15. PMID 11080149, Free PMC Article
    2. Vezatin, a protein associated to adherens junctions, is required for mouse blastocyst morphogenesis. Hyenne V, et al. Dev Biol, 2005 Nov 1. PMID 16199027
    3. Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning. Michalski N, et al. J Neurosci, 2007 Jun 13. PMID 17567809, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94969

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables myosin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chordate embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synapse maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of stereocilia ankle link complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of stereocilia ankle link complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in stereocilium membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vezatin
    Names
    transmembrane protein vezatin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006984.1 → NP_001006985.1  vezatin

      See identical proteins and their annotated locations for NP_001006985.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083840
      UniProtKB/Swiss-Prot
      Q5XI52
      UniProtKB/TrEMBL
      A6IFZ9, A6IG00
      Conserved Domains (1) summary
      pfam12632
      Location:150 → 442
      Vezatin; Mysoin-binding motif of peroxisomes

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      30399208..30484429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078694.2 → XP_038934622.1  vezatin isoform X1

      UniProtKB/TrEMBL
      A6IG00
      Conserved Domains (1) summary
      pfam12632
      Location:150 → 438
      Vezatin; Mysoin-binding motif of peroxisomes

    2. XM_017594734.3 → XP_017450223.1  vezatin isoform X5

      UniProtKB/TrEMBL
      A0A8L2QL87, A6IFZ8
      Related
      ENSRNOP00000038458.5, ENSRNOT00000030015.6

    3. XM_039078696.2 → XP_038934624.1  vezatin isoform X3

      UniProtKB/TrEMBL
      A6IFZ8
      Conserved Domains (1) summary
      pfam12632
      Location:150 → 442
      Vezatin; Mysoin-binding motif of peroxisomes

    4. XM_063263203.1 → XP_063119273.1  vezatin isoform X6

      UniProtKB/TrEMBL
      A6IG00

    5. XM_039078697.2 → XP_038934625.1  vezatin isoform X4

      UniProtKB/TrEMBL
      A6IG01
      Conserved Domains (1) summary
      pfam12632
      Location:42 → 278
      Vezatin; Mysoin-binding motif of peroxisomes

    6. XM_063263202.1 → XP_063119272.1  vezatin isoform X2

      UniProtKB/TrEMBL
      A6IG01

    RNA

    1. XR_005486572.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI52.1 GenPept UniProtKB/Swiss-Prot:Q5XI52

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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