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    Gfus GDP-L-fucose synthase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300036, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gfusprovided by RGD
    Official Full Name
    GDP-L-fucose synthaseprovided by RGD
    Primary source
    RGD:1307028
    See related
    EnsemblRapid:ENSRNOG00000009020 AllianceGenome:RGD:1307028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tsta3
    Summary
    Predicted to enable GDP-L-fucose synthase activity; GDP-mannose 3,5-epimerase activity; and identical protein binding activity. Predicted to be involved in 'de novo' GDP-L-fucose biosynthetic process; positive regulation of endothelial cell migration; and positive regulation of endothelial cell-matrix adhesion via fibronectin. Predicted to act upstream of or within T cell mediated cytotoxicity. Predicted to be located in cytosol. Orthologous to human GFUS (GDP-L-fucose synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 225.4), Kidney (RPKM 194.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gfus in Genome Data Viewer
    Location:
    7q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109492808..109497719, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (107612087..107617005, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (116958427..116963281, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 delta Neighboring gene tigger transposable element derived 5 Neighboring gene pyrroline-5-carboxylate reductase 3 Neighboring gene zinc finger protein 623 Neighboring gene uncharacterized LOC120093815 Neighboring gene zinc finger protein 707-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The crystal structure of human GDP-L-fucose synthase. Zhou H, et al. Acta Biochim Biophys Sin (Shanghai), 2013 Sep. PMID 23774504
    2. Synthesis of GDP-L-fucose by the human FX protein. Tonetti M, et al. J Biol Chem, 1996 Nov 1. PMID 8910301
    3. Structure of the gene of tum- transplantation antigen P91A: the mutated exon encodes a peptide recognized with Ld by cytolytic T cells. Lurquin C, et al. Cell, 1989 Jul 28. PMID 2568889
    4. Involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis(y) (CD174) in first endothelial cell-cell contacts during angiogenesis. Moehler TM, et al. J Cell Physiol, 2008 Apr. PMID 18205178
    5. Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro. Sullivan FX, et al. J Biol Chem, 1998 Apr 3. PMID 9525924

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP-L-fucose synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP-L-fucose synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP-mannose 3,5-epimerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' GDP-L-fucose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' GDP-L-fucose biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GDP-mannose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GDP-L-fucose synthase
    Names
    GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase
    tissue specific transplantation antigen P35B
    NP_001120927.1
    NP_001257718.1
    NP_001257719.1
    XP_063119377.1
    XP_063119378.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127455.2 → NP_001120927.1  GDP-L-fucose synthase isoform a

      See identical proteins and their annotated locations for NP_001120927.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      BC158885, BF289545
      UniProtKB/TrEMBL
      A0A8I6A7C3, A6HS39
      Related
      ENSRNOP00000087082.1, ENSRNOT00000100492.2
      Conserved Domains (1) summary
      cd05239
      Location:9 → 312
      GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs

    2. NM_001270789.1 → NP_001257718.1  GDP-L-fucose synthase isoform a

      See identical proteins and their annotated locations for NP_001257718.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      BC158885, BF289545, CA339313
      UniProtKB/TrEMBL
      A0A8I6A7C3, A6HS39
      Related
      ENSRNOP00000012306.5, ENSRNOT00000012306.9
      Conserved Domains (1) summary
      cd05239
      Location:9 → 312
      GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs

    3. NM_001270790.1 → NP_001257719.1  GDP-L-fucose synthase isoform b

      See identical proteins and their annotated locations for NP_001257719.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BC158885, BF289545
      UniProtKB/TrEMBL
      B0BNN0
      Related
      ENSRNOP00000071672.1, ENSRNOT00000082058.3
      Conserved Domains (2) summary
      cd05239
      Location:9 → 269
      GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs
      pfam01370
      Location:10 → 202
      Epimerase; NAD dependent epimerase/dehydratase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      109492808..109497719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263308.1 → XP_063119378.1  GDP-L-fucose synthase isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7C3, A6HS39

    2. XM_063263307.1 → XP_063119377.1  GDP-L-fucose synthase isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7C3, A6HS39

    RNA

    1. XR_005486584.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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