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    Cfhr4 complement factor H-related 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498241, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cfhr4provided by RGD
    Official Full Name
    complement factor H-related 4provided by RGD
    Primary source
    RGD:1564614
    See related
    EnsemblRapid:ENSRNOG00000042369 AllianceGenome:RGD:1564614
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564614
    Summary
    Predicted to enable complement component C3b binding activity and heparin binding activity. Predicted to be involved in complement activation. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to several human genes including CFH (complement factor H). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 926.9) See more
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    Genomic context

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    See Cfhr4 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (53973301..54042179, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (51422592..51491476, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (56889669..56958549, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene complement factor H-related 1, pseudogene 1 Neighboring gene complement factor H-related 1 Neighboring gene POU domain, class 5, transcription factor 1 pseudogene Neighboring gene vomeronasal 2 receptor, pseudogene 111 Neighboring gene complement factor H Neighboring gene heterogeneous nuclear ribonucleoprotein C, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a novel rat factor H-related protein that is up-regulated in glomeruli under complement attack. Ren G, et al. J Biol Chem, 2002 Dec 13. PMID 12374811
    2. Two factor H-related proteins from the mouse: expression analysis and functional characterization. Hellwage J, et al. Immunogenetics, 2006 Nov. PMID 17028856
    3. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Bastos-Amador P, et al. J Proteomics, 2012 Jun 27. PMID 22516433
    4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables complement component C3b binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables complement component C3b binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in complement activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    complement factor H-related 4
    Names
    complement factor H-related protein
    complement factor H-related protein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134792.1 → NP_001128264.1  complement factor H-related 4 precursor

      See identical proteins and their annotated locations for NP_001128264.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6ICN0, G3V7P5, Q91WX0
      Related
      ENSRNOP00000017293.1, ENSRNOT00000017293.5
      Conserved Domains (3) summary
      cd00033
      Location:578 → 632
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:143 → 382
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:448 → 501
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      53973301..54042179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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