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    Tnfsf13b TNF superfamily member 13b [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498666, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tnfsf13bprovided by RGD
    Official Full Name
    TNF superfamily member 13bprovided by RGD
    Primary source
    RGD:1561519
    See related
    EnsemblRapid:ENSRNOG00000014464 AllianceGenome:RGD:1561519
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BAFF; Tnlg7a; RGD1561519
    Summary
    Predicted to enable receptor ligand activity. Predicted to be involved in positive regulation of B cell proliferation and tumor necrosis factor-mediated signaling pathway. Predicted to act upstream of or within several processes, including positive regulation of germinal center formation; positive regulation of lymphocyte activation; and transitional one stage B cell differentiation. Predicted to be located in several cellular components, including focal adhesion; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in extracellular space. Orthologous to human TNFSF13B (TNF superfamily member 13b). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 48.8), Lung (RPKM 29.2) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tnfsf13b in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (86164377..86195072, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (79462406..79492888, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (85275690..85306419, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103694008 Neighboring gene uncharacterized LOC120097572 Neighboring gene myosin XVI Neighboring gene abhydrolase domain containing 13 Neighboring gene DNA ligase 4

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell costimulation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within B cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within T cell costimulation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of germinal center formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of B cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of germinal center formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skin development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within transitional one stage B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor ligand superfamily member 13B
    Names
    B-cell-activating factor
    tumor necrosis factor (ligand) superfamily, member 13b
    tumor necrosis factor ligand 7a
    tumor necrosis factor superfamily member 13b

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395721.1NP_001382650.1  tumor necrosis factor ligand superfamily member 13B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A096MJG3, A0A0U5JXV5
      Related
      ENSRNOP00000073755.2, ENSRNOT00000089650.3
      Conserved Domains (1) summary
      cd00184
      Location:154290
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      86164377..86195072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253483.5XP_006253545.1  tumor necrosis factor ligand superfamily member 13B isoform X3

      UniProtKB/TrEMBL
      A0A096MJG3, A0A0G2K6C2
      Conserved Domains (1) summary
      cd00184
      Location:143271
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    2. XM_006253481.5XP_006253543.1  tumor necrosis factor ligand superfamily member 13B isoform X2

      See identical proteins and their annotated locations for XP_006253543.1

      UniProtKB/TrEMBL
      A0A096MJG3, A6IWR7
      Related
      ENSRNOP00000068118.3, ENSRNOT00000076737.4
      Conserved Domains (1) summary
      cd00184
      Location:180303
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    3. XM_006253480.5XP_006253542.1  tumor necrosis factor ligand superfamily member 13B isoform X1

      See identical proteins and their annotated locations for XP_006253542.1

      UniProtKB/TrEMBL
      A0A096MJG3, A6IWR8, D3ZFD8
      Related
      ENSRNOP00000062950.2, ENSRNOT00000067511.4
      Conserved Domains (1) summary
      cd00184
      Location:186322
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    4. XM_063275652.1XP_063131722.1  tumor necrosis factor ligand superfamily member 13B isoform X4

      UniProtKB/TrEMBL
      A6IWR9

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001109112.1: Suppressed sequence

      Description
      NM_001109112.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.