Mob4 MOB family member 4, phocein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mob4provided by RGD
Official Full Name: MOB family member 4, phoceinprovided by RGD
Primary source: RGD:620183
See related: EnsemblRapid:ENSRNOG00000014980 AllianceGenome:RGD:620183
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Phocn; Prei3; Mobkl1; Mobkl3; phocein
Summary: Enables kinase binding activity. Predicted to be involved in negative regulation of hippo signaling. Located in several cellular components, including dendritic spine; neuronal cell body; and perinuclear region of cytoplasm. Orthologous to human MOB4 (MOB family member 4, phocein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 789.0), Brain (RPKM 254.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (64111170..64135740)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (56617374..56641336)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (61720583..61744532)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zinedin is primarily expressed in neurons of the hippocampus, cerebral cortex, olfactory bulb and caudate putamen nucleus. AND displays a polarized distribution in the somato-dendritic compartment of neurons and is enriched in dendritic spines.
Title: Distribution of zinedin in the rat brain.
interaction with nucleoside-diphosphate kinase, eps15, and dynamin I (phocein)
Title: Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143767 (e-PCR)
- UniSTS:233013

D9Mco76 (e-PCR)
- UniSTS:526182

AA818419 (e-PCR)
- UniSTS:249713

RH138957 (e-PCR)
- UniSTS:221043

RH140245 (e-PCR)
- UniSTS:222324

Mobkl3 (e-PCR), detects polymorphism
- UniSTS:532889

RH129911 (e-PCR)
- UniSTS:213199

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hippo signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle budding from membrane	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	ISO Inferred from Sequence Orthology more info
part_of FAR/SIN/STRIPAK complex	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: MOB-like protein phocein

Names: MOB1, Mps One Binder kinase activator-like 3; class II mMOB1; mob1 homolog 3; mob3; mps one binder kinase activator-like 3; phocein, Mob-like protein; preimplantation protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.