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    Frmd3 FERM domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298141, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Frmd3provided by RGD
    Official Full Name
    FERM domain containing 3provided by RGD
    Primary source
    RGD:1304802
    See related
    EnsemblRapid:ENSRNOG00000006503 AllianceGenome:RGD:1304802
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cytoskeletal protein binding activity. Predicted to be involved in actomyosin structure organization. Predicted to be located in membrane. Predicted to be active in cytoskeleton. Orthologous to human FRMD3 (FERM domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 39.3), Muscle (RPKM 11.4) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Frmd3 in Genome Data Viewer
    Location:
    5q31
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (92810989..93077326)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (87764755..88031091)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (90040495..90282327, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310002L09 like Neighboring gene dnaJ homolog subfamily B member 1 pseudogene Neighboring gene protein disulfide-isomerase A5 pseudogene Neighboring gene COMM domain-containing protein 2 pseudogene Neighboring gene developmental pluripotency-associated 3, pseudogene 2 Neighboring gene lysine demethylase 4C Neighboring gene protein kinase C iota type-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FERM domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415819.2 → NP_001402748.1  FERM domain-containing protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZT99, A6J815, D3ZR47
      Related
      ENSRNOP00000081802.1, ENSRNOT00000099661.2

    2. NM_001415820.1 → NP_001402749.1  FERM domain-containing protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6AMS8, A6J815, D3ZR47
      Related
      ENSRNOP00000095070.1, ENSRNOT00000100906.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      92810989..93077326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109494.2 → XP_038965422.1  FERM domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A6J815, D3ZR47
      Conserved Domains (3) summary
      smart00295
      Location:1 → 143
      B41; Band 4.1 homologues
      pfam08736
      Location:241 → 283
      FA; FERM adjacent (FA)
      cl17171
      Location:124 → 227
      PH-like; Pleckstrin homology-like domain

    2. XM_063287360.1 → XP_063143430.1  FERM domain-containing protein 3 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
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