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    Rmdn2 regulator of microtubule dynamics 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313840, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rmdn2provided by RGD
    Official Full Name
    regulator of microtubule dynamics 2provided by RGD
    Primary source
    RGD:1559836
    See related
    EnsemblRapid:ENSRNOG00000006082 AllianceGenome:RGD:1559836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam82a; Fam82a1
    Summary
    Predicted to enable microtubule binding activity. Predicted to be located in Golgi apparatus; cytosol; and mitotic spindle. Predicted to be active in mitochondrion; mitotic spindle pole; and spindle microtubule. Orthologous to human RMDN2 (regulator of microtubule dynamics 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 265.2), Liver (RPKM 178.8) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rmdn2 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (21101383..21195221, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (15372569..15443000, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (2215062..2292288)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351158 Neighboring gene uncharacterized LOC102554703 Neighboring gene uncharacterized LOC134479104 Neighboring gene uncharacterized LOC134479105 Neighboring gene cytochrome P450, family 1, subfamily b, polypeptide 1 Neighboring gene uncharacterized LOC134479325 Neighboring gene uncharacterized LOC134479326

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of Hepatocytes in G0 and G1 Phases by NOTCH3 mRNA, miR-369-3p, and rno-Rmdn2_0006 during the Initial Stage of Rat Liver Regeneration. Zang X, et al. Genet Res (Camb), 2023. PMID 37153858, Free PMC Article
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of Hepatocytes in G0 and G1 Phases by NOTCH3 mRNA, miR-369-3p, and rno-Rmdn2_0006 during the Initial Stage of Rat Liver Regeneration.
      Title: Regulation of Hepatocytes in G0 and G1 Phases by NOTCH3 mRNA, miR-369-3p, and rno-Rmdn2_0006 during the Initial Stage of Rat Liver Regeneration.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116304

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitotic spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    regulator of microtubule dynamics protein 2
    Names
    RMD-2
    family with sequence similarity 82, member A
    family with sequence similarity 82, member A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037200.2 → NP_001032277.1  regulator of microtubule dynamics protein 2

      See identical proteins and their annotated locations for NP_001032277.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q498D5
      UniProtKB/TrEMBL
      A0A8I6APZ8
      Related
      ENSRNOP00000094581.2, ENSRNOT00000097853.2

    2. NM_001401322.1 → NP_001388251.1  regulator of microtubule dynamics protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q498D5
      UniProtKB/TrEMBL
      A0A8I6APZ8
      Related
      ENSRNOP00000008045.5, ENSRNOT00000008045.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      21101383..21195221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261813.1 → XP_063117883.1  regulator of microtubule dynamics protein 2 isoform X4

    2. XM_063261811.1 → XP_063117881.1  regulator of microtubule dynamics protein 2 isoform X4

    3. XM_063261816.1 → XP_063117886.1  regulator of microtubule dynamics protein 2 isoform X4

    4. XM_063261806.1 → XP_063117876.1  regulator of microtubule dynamics protein 2 isoform X4

    5. XM_063261809.1 → XP_063117879.1  regulator of microtubule dynamics protein 2 isoform X4

    6. XM_063261810.1 → XP_063117880.1  regulator of microtubule dynamics protein 2 isoform X4

      Related
      ENSRNOP00000099447.1, ENSRNOT00000135381.1

    7. XM_063261815.1 → XP_063117885.1  regulator of microtubule dynamics protein 2 isoform X4

    8. XM_063261808.1 → XP_063117878.1  regulator of microtubule dynamics protein 2 isoform X4

    9. XM_063261807.1 → XP_063117877.1  regulator of microtubule dynamics protein 2 isoform X4

    10. XM_063261814.1 → XP_063117884.1  regulator of microtubule dynamics protein 2 isoform X4

    11. XM_063261823.1 → XP_063117893.1  regulator of microtubule dynamics protein 2 isoform X8

    12. XM_063261805.1 → XP_063117875.1  regulator of microtubule dynamics protein 2 isoform X1

    13. XM_063261818.1 → XP_063117888.1  regulator of microtubule dynamics protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AMI8, A0A8I6APZ8, A6H9T4

    14. XM_063261819.1 → XP_063117889.1  regulator of microtubule dynamics protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AMI8, A0A8I6APZ8, A6H9T4

    15. XM_063261820.1 → XP_063117890.1  regulator of microtubule dynamics protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AMI8, A0A8I6APZ8, A6H9T4

    16. XM_063261817.1 → XP_063117887.1  regulator of microtubule dynamics protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AMI8, A0A8I6APZ8, A6H9T4

    17. XM_063261824.1 → XP_063117894.1  regulator of microtubule dynamics protein 2 isoform X9

    18. XM_006239634.4 → XP_006239696.1  regulator of microtubule dynamics protein 2 isoform X3

      Related
      ENSRNOP00000108871.1, ENSRNOT00000162974.1

    19. XM_039112140.2 → XP_038968068.1  regulator of microtubule dynamics protein 2 isoform X11

    20. XM_039112131.2 → XP_038968059.1  regulator of microtubule dynamics protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6APZ8

    21. XM_063261822.1 → XP_063117892.1  regulator of microtubule dynamics protein 2 isoform X7

      UniProtKB/Swiss-Prot
      Q498D5
      UniProtKB/TrEMBL
      A0A8I6APZ8

    22. XM_039112133.2 → XP_038968061.1  regulator of microtubule dynamics protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6APZ8

    23. XM_063261825.1 → XP_063117895.1  regulator of microtubule dynamics protein 2 isoform X10

    24. XM_039112130.2 → XP_038968058.1  regulator of microtubule dynamics protein 2 isoform X2

      Related
      ENSRNOP00000085138.2, ENSRNOT00000111637.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q498D5.1 GenPept UniProtKB/Swiss-Prot:Q498D5

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