Arhgap31 Rho GTPase activating protein 31 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arhgap31provided by RGD
Official Full Name: Rho GTPase activating protein 31provided by RGD
Primary source: RGD:1306093
See related: EnsemblRapid:ENSRNOG00000003088 AllianceGenome:RGD:1306093
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cdgap
Summary: Predicted to enable GTPase activator activity and SH3 domain binding activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be active in lamellipodium. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and coronary artery disease. Orthologous to human ARHGAP31 (Rho GTPase activating protein 31). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 218.6), Heart (RPKM 119.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q21

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (75544176..75657087)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (62038635..62151564)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (64600968..64714114)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D11Rat83 (e-PCR), detects polymorphism
- UniSTS:226429

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 31

Names: Cdc42 GTPase-activating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105879.1 → NP_001099349.1 rho GTPase-activating protein 31

See identical proteins and their annotated locations for NP_001099349.1

Status: PROVISIONAL

Source sequence(s)

CH473967

UniProtKB/TrEMBL

A0A8I6AML1, A6IR57, D4A987

Related

ENSRNOP00000004138.4, ENSRNOT00000004138.7

Conserved Domains (2) summary

cd04384
Location:17 → 211

RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

pfam06136
Location:1189 → 1306

DUF966; Domain of unknown function (DUF966)