Prkcg protein kinase C, gamma [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prkcgprovided by RGD
Official Full Name: protein kinase C, gammaprovided by RGD
Primary source: RGD:3397
See related: EnsemblRapid:ENSRNOG00000054371 AllianceGenome:RGD:3397
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PKC; PKCI; Prkc; Prkcc; RATPKCI
Summary: Enables calcium,diacylglycerol-dependent serine/threonine kinase activity. Involved in several processes, including long-term synaptic potentiation; response to angiotensin; and response to psychosocial stress. Located in several cellular components, including dendrite; perinuclear region of cytoplasm; and synaptic membrane. Is active in postsynaptic cytosol. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 14. Orthologous to human PRKCG (protein kinase C gamma). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 143.9), Spleen (RPKM 12.0) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (74748272..74777611, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (65832851..65860676, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (64407098..64433698, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NETO2-GluK2 interaction contributes to postoperative pain hypersensitivity through inducing PKCgamma activation and synaptic incorporation of AMPA receptor GluR1 subunits in rat dorsal horn.
Title: NETO2-GluK2 interaction contributes to postoperative pain hypersensitivity through inducing PKCγ activation and synaptic incorporation of AMPA receptor GluR1 subunits in rat dorsal horn.
Sex-specific effects of 17beta-estradiol and dihydrotestosterone (DHT) on growth plate chondrocytes are dependent on both ERalpha and ERbeta and require palmitoylation to translocate the receptors to the plasma membrane.
Title: Sex-specific effects of 17β-estradiol and dihydrotestosterone (DHT) on growth plate chondrocytes are dependent on both ERα and ERβ and require palmitoylation to translocate the receptors to the plasma membrane.
Pain modulation effect on motor cortex after optogenetic stimulation in shPKCgamma knockdown dorsal root ganglion-compressed Sprague-Dawley rat model.
Title: Pain modulation effect on motor cortex after optogenetic stimulation in shPKCγ knockdown dorsal root ganglion-compressed Sprague-Dawley rat model.
Prenatal stress possibly decreases hippocampal PKCgamma activity, resulting in a reduction of p-GAP-43 and p-Ng, which underlies insufficient CaMKII activation, thereby impairing spatial learning and memory.
Title: Hippocampal Protein Kinase C Gamma Signaling Mediates the Impairment of Spatial Learning and Memory in Prenatally Stressed Offspring Rats.
A 5-HT2A receptor to protein kinase C gamma pathway leads to the behavioral allodynia and morphological changes in protein kinase C gamma interneurons.
Title: 5-HT(2A) Receptor-Induced Morphological Reorganization of PKCγ-Expressing Interneurons Gates Inflammatory Mechanical Allodynia in Rat.
acute stress causes the enhancement of acid-sensing ion channels function by activating PKC signaling pathway, which leads to potentiated learning and memory.
Title: Acute stress enhances learning and memory by activating acid-sensing ion channels in rats.
It could be activated by hyperglycemia induced inflammatory reaction.
Title: Berberine Ameliorates Diabetic Neuropathy: TRPV1 Modulation by PKC Pathway.
In summary, ionomycin-promoted exocytosis of GLUT4 is partly reversed by siPKCtheta;, whereas ionomycin-inhibited endocytosis of GLUT4 requires both siPKCalpha and siPKCtheta;. PKCalpha and PKCtheta; contribute to ionomycin-induced phosphorylation of AS160 and TBC1D1. Rab13 is required for ionomycin-regulated GLUT4 exocytosis.
Title: PKC and Rab13 mediate Ca(2+) signal-regulated GLUT4 traffic.
PKC phosphorylates cardiac troponin I (cTnI) S23/24, S43/45 and T144 to fine tune myocyte function.
Title: Functional communication between PKC-targeted cardiac troponin I phosphorylation sites.
In a model of cancer-induced bone pain, protein kinase C gamma is up-regulated in the spine.
Title: Involvement of Spinal CCR5/PKCγ Signaling Pathway in the Maintenance of Cancer-Induced Bone Pain.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Prkcc (e-PCR), detects polymorphism
- UniSTS:531458

D1Arb31 (e-PCR)
- UniSTS:240136

fc30h10.x1 (e-PCR)
- UniSTS:187950

Prkcc (e-PCR), detects polymorphism
- UniSTS:144194

Pkcc (e-PCR)
- UniSTS:144195

D1Mco31 (e-PCR)
- UniSTS:240510

D1Wox11 (e-PCR)
- UniSTS:117942

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium,diacylglycerol-dependent serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium,diacylglycerol-dependent serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine/tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within chemosensory behavior	ISO Inferred from Sequence Orthology more info
involved_in innervation	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in learning or memory	IEP Inferred from Expression Pattern more info	PubMed
involved_in long-term synaptic potentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteasomal protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mismatch repair	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell communication	IEA Inferred from Electronic Annotation more info
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of response to food	ISO Inferred from Sequence Orthology more info
involved_in regulation of response to food	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of signaling	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in response to angiotensin	IDA Inferred from Direct Assay more info	PubMed
involved_in response to morphine	ISO Inferred from Sequence Orthology more info
involved_in response to morphine	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to pain	ISO Inferred from Sequence Orthology more info
involved_in response to pain	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to psychosocial stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in calyx of Held	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic cytosol	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein kinase C gamma type

Names: PKC-gamma; protein kinase C type I (gamma type)

NP_036760.1

EC 2.7.11.13

XP_006228076.1

EC 2.7.11.13

XP_038956627.1

EC 2.7.11.13

XP_038956664.1

EC 2.7.11.13

XP_038956684.1

EC 2.7.11.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012628.2 → NP_036760.1 protein kinase C gamma type

See identical proteins and their annotated locations for NP_036760.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P63319, Q5FWS3

UniProtKB/TrEMBL

A6KS41

Related

ENSRNOP00000071203.1, ENSRNOT00000080032.3

Conserved Domains (4) summary

cd04026
Location:158 → 289

C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma

cd05587
Location:354 → 677

STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C

cd20833
Location:34 → 91

C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

cd20836
Location:101 → 154

C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

74748272..74777611 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006228014.5 → XP_006228076.1 protein kinase C gamma type isoform X1

See identical proteins and their annotated locations for XP_006228076.1

UniProtKB/TrEMBL

A0A8I5ZN16

Related

ENSRNOP00000079620.1, ENSRNOT00000104999.2

Conserved Domains (4) summary

cd04026
Location:158 → 289

C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma

cd05587
Location:312 → 626

STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C

cd20833
Location:34 → 91

C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

cd20836
Location:101 → 154

C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
XM_039100736.2 → XP_038956664.1 protein kinase C gamma type isoform X2

Conserved Domains (3) summary

cd04026
Location:30 → 161

C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma

cd05587
Location:226 → 549

STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C

cl00040
Location:1 → 26

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_039100699.2 → XP_038956627.1 protein kinase C gamma type isoform X2

Conserved Domains (3) summary

cd04026
Location:30 → 161

C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma

cd05587
Location:226 → 549

STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C

cl00040
Location:1 → 26

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_039100756.1 → XP_038956684.1 protein kinase C gamma type isoform X3

Conserved Domains (1) summary

cd05587
Location:52 → 375

STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C