Fcmr Fc mu receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fcmrprovided by RGD
Official Full Name: Fc mu receptorprovided by RGD
Primary source: RGD:1359282
See related: EnsemblRapid:ENSRNOG00000004441 AllianceGenome:RGD:1359282
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Toso; Faim3; FAIM3g; IgM FcR
Summary: Predicted to enable IgM binding activity; high-affinity IgM receptor activity; and polymeric immunoglobulin binding activity. Predicted to be involved in several processes, including Fc receptor-mediated immune complex endocytosis; humoral immune response mediated by circulating immunoglobulin; and regulation of B cell receptor signaling pathway. Predicted to act upstream of or within inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; and negative regulation of lymphocyte apoptotic process. Predicted to be located in bounding membrane of organelle; external side of plasma membrane; and trans-Golgi network membrane. Predicted to be active in plasma membrane. Orthologous to human FCMR (Fc mu receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 267.7), Thymus (RPKM 47.9) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (44889628..44903926)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (42337363..42351706)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (47602701..47617065)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

D13Got21 (e-PCR)
- UniSTS:113175

D13Got29 (e-PCR)
- UniSTS:112852

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables IgM binding	ISO Inferred from Sequence Orthology more info
enables IgM binding	ISS Inferred from Sequence or Structural Similarity more info
enables high-affinity IgM receptor activity	ISO Inferred from Sequence Orthology more info
enables high-affinity IgM receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables polymeric immunoglobulin binding	ISO Inferred from Sequence Orthology more info
enables polymeric immunoglobulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Fc receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Fc receptor-mediated immune complex endocytosis	ISO Inferred from Sequence Orthology more info
involved_in Fc receptor-mediated immune complex endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in humoral immune response mediated by circulating immunoglobulin	ISO Inferred from Sequence Orthology more info
involved_in humoral immune response mediated by circulating immunoglobulin	ISS Inferred from Sequence or Structural Similarity more info
involved_in immunoglobulin transcytosis in epithelial cells	ISO Inferred from Sequence Orthology more info
involved_in immunoglobulin transcytosis in epithelial cells	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of lymphocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of B cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: immunoglobulin mu Fc receptor

Names: Fas apoptotic inhibitory molecule 3; Fc fragment of IgM receptor; IgM Fc fragment receptor; regulator of Fas-induced apoptosis Toso

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014843.2 → NP_001014843.1 immunoglobulin mu Fc receptor precursor

See identical proteins and their annotated locations for NP_001014843.1

Status: VALIDATED

Source sequence(s)

BC088197, JAXUCZ010000013

UniProtKB/Swiss-Prot

Q5M871

UniProtKB/TrEMBL

A0A8I5ZSV7

Related

ENSRNOP00000036615.5, ENSRNOT00000038822.7

Conserved Domains (2) summary

cd05716
Location:27 → 120

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:25 → 121

IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

44889628..44903926

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249715.5 → XP_006249777.1 immunoglobulin mu Fc receptor isoform X1

UniProtKB/TrEMBL

A0A0H2UHV3, A6IC06

Conserved Domains (2) summary

cd05716
Location:48 → 141

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:46 → 142

IG_like; Immunoglobulin like