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    Gmfg glia maturation factor, gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113940, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gmfgprovided by RGD
    Official Full Name
    glia maturation factor, gammaprovided by RGD
    Primary source
    RGD:620506
    See related
    EnsemblRapid:ENSRNOG00000019838 AllianceGenome:RGD:620506
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable Arp2/3 complex binding activity. Predicted to be involved in actin filament debranching and negative regulation of Arp2/3 complex-mediated actin nucleation. Predicted to be active in cortical actin cytoskeleton. Orthologous to human GMFG (glia maturation factor gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 1010.3), Spleen (RPKM 387.3) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gmfg in Genome Data Viewer
    Location:
    1q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (92856154..92866722)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (83728797..83739189)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (85312473..85322860, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene PAF1 homolog, Paf1/RNA polymerase II complex component Neighboring gene sterile alpha motif domain containing 4B Neighboring gene leucine rich repeat and fibronectin type III domain containing 1 Neighboring gene interferon, lambda 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning of a rat glia maturation factor-gamma (rGMFG) cDNA and expression of its mRNA and protein in rat organs. Tsuiki H, et al. J Biochem, 2000 Mar. PMID 10731725
    2. GMF severs actin-Arp2/3 complex branch junctions by a cofilin-like mechanism. Ydenberg CA, et al. Curr Biol, 2013 Jun 17. PMID 23727094, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Arp2/3 complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase regulator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament debranching IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament debranching IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within actin filament debranching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glia maturation factor gamma
    Names
    GMF-gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429255.1 → NP_001416184.1  glia maturation factor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q80T18
      UniProtKB/TrEMBL
      A6J9J2

    2. NM_001429256.1 → NP_001416185.1  glia maturation factor gamma isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q80T18
      UniProtKB/TrEMBL
      A0A8I6GI11

    3. NM_001429257.1 → NP_001416186.1  glia maturation factor gamma isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    4. NM_001429258.1 → NP_001416187.1  glia maturation factor gamma isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AD83, A6J9J4

    5. NM_001429259.1 → NP_001416188.1  glia maturation factor gamma isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AD83, A6J9J4

    6. NM_181091.3 → NP_851605.2  glia maturation factor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q80T18
      UniProtKB/TrEMBL
      A6J9J2
      Related
      ENSRNOP00000026891.6, ENSRNOT00000026891.8

    RNA

    1. NR_190702.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      92856154..92866722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288517.1 → XP_063144587.1  glia maturation factor gamma isoform X1

    2. XM_006228606.5 → XP_006228668.3  glia maturation factor gamma isoform X2

      Related
      ENSRNOP00000089766.2, ENSRNOT00000118600.2

    3. XM_063288636.1 → XP_063144706.1  glia maturation factor gamma isoform X6

    4. XM_063288563.1 → XP_063144633.1  glia maturation factor gamma isoform X3

    5. XM_063288623.1 → XP_063144693.1  glia maturation factor gamma isoform X6

    6. XM_039105677.2 → XP_038961605.1  glia maturation factor gamma isoform X4

      Related
      ENSRNOP00000089358.1, ENSRNOT00000118560.2
      Conserved Domains (1) summary
      cd11283
      Location:10 → 131
      ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

    7. XM_063288604.1 → XP_063144674.1  glia maturation factor gamma isoform X5

    RNA

    1. XR_010066526.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80T18.1 GenPept UniProtKB/Swiss-Prot:Q80T18

    Gene LinkOut

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