Mrpl46 mitochondrial ribosomal protein L46 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mrpl46provided by RGD
Official Full Name: mitochondrial ribosomal protein L46provided by RGD
Primary source: RGD:1309123
See related: EnsemblRapid:ENSRNOG00000018547 AllianceGenome:RGD:1309123
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be a structural constituent of ribosome. Predicted to be located in cell junction; mitochondrion; and nucleoplasm. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL46 (mitochondrial ribosomal protein L46). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 125.9), Muscle (RPKM 112.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q31

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (142108266..142117030, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (132698872..132707639, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (140469557..140477634, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
part_of mitochondrial large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial large ribosomal subunit	ISO Inferred from Sequence Orthology more info
part_of mitochondrial large ribosomal subunit	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: large ribosomal subunit protein mL46

Names: 39S ribosomal protein L46, mitochondrial; L46mt; MRP-L46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013068.1 → NP_001013086.1 large ribosomal subunit protein mL46

See identical proteins and their annotated locations for NP_001013086.1

Status: PROVISIONAL

Source sequence(s)

BC086407

UniProtKB/Swiss-Prot

Q5RK00

UniProtKB/TrEMBL

A6JC25

Related

ENSRNOP00000061438.1, ENSRNOT00000067172.4

Conserved Domains (2) summary

cd04661
Location:142 → 273

MRP_L46; Mitochondrial ribosomal protein L46 (MRP L46) is a component of the large subunit (39S) of the mammalian mitochondrial ribosome and a member of the Nudix hydrolase superfamily. MRPs are thought to be involved in the maintenance of the mitochondrial DNA. ...

pfam11788
Location:43 → 139

MRP-L46; 39S mitochondrial ribosomal protein L46