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    Adgre5 adhesion G protein-coupled receptor E5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361383, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adgre5provided by RGD
    Official Full Name
    adhesion G protein-coupled receptor E5provided by RGD
    Primary source
    RGD:1305595
    See related
    EnsemblRapid:ENSRNOG00000004489 AllianceGenome:RGD:1305595
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cd97
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in vibratory urticaria. Orthologous to several human genes including ADGRE5 (adhesion G protein-coupled receptor E5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 659.8), Spleen (RPKM 245.2) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adgre5 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (41302687..41332183)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (24397972..24418648)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (24854981..24875712, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483629 Neighboring gene uncharacterized LOC134483630 Neighboring gene uncharacterized LOC134483332 Neighboring gene transfer RNA alanine (anticodon AGC) 20 Neighboring gene DExD-box helicase 39A Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120098561 Neighboring gene protein kinase N1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CD97, but not its closely related EGF-TM7 family member EMR2, is expressed on gastric, pancreatic, and esophageal carcinomas. Aust G, et al. Am J Clin Pathol, 2002 Nov. PMID 12428789
    2. Complement factor H, a marker of self protects against experimental autoimmune encephalomyelitis. Griffiths MR, et al. J Immunol, 2009 Apr 1. PMID 19299737
    3. Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Um JW, et al. Cell Rep, 2014 Mar 27. PMID 24613359, Free PMC Article
    4. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
    5. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor E5
    Names
    CD97 antigen
    CD97 molecule

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012164.1 → NP_001012164.1  adhesion G protein-coupled receptor E5 precursor

      See identical proteins and their annotated locations for NP_001012164.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083857
      UniProtKB/TrEMBL
      A0A8I6G2Z6, E9PT32, Q5XI36
      Related
      ENSRNOP00000079017.2, ENSRNOT00000115153.2
      Conserved Domains (4) summary
      smart00179
      Location:69 → 101
      EGF_CA; Calcium-binding EGF-like domain
      pfam00002
      Location:534 → 773
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam01825
      Location:487 → 526
      GPS; GPCR proteolysis site, GPS, motif
      pfam07645
      Location:171 → 218
      EGF_CA; Calcium-binding EGF domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      41302687..41332183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278115.1 → XP_063134185.1  adhesion G protein-coupled receptor E5 isoform X3

      UniProtKB/TrEMBL
      A0A8I6G2Z6

    2. XM_063278116.1 → XP_063134186.1  adhesion G protein-coupled receptor E5 isoform X6

      UniProtKB/TrEMBL
      A0A8I6G2Z6

    3. XM_063278114.1 → XP_063134184.1  adhesion G protein-coupled receptor E5 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZM38

    4. XM_006255278.4 → XP_006255340.3  adhesion G protein-coupled receptor E5 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JSI4, A0A8I5ZM38
      Related
      ENSRNOP00000111454.1, ENSRNOT00000135529.1

    5. XM_006255279.4 → XP_006255341.3  adhesion G protein-coupled receptor E5 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZM38
      Related
      ENSRNOP00000006152.8, ENSRNOT00000006152.9

    6. XM_006255281.4 → XP_006255343.3  adhesion G protein-coupled receptor E5 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZM38
    Nucleotide Protein Strain
    Heading Accession and Version

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