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    Casp8ap2 caspase 8 associated protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313128, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Casp8ap2provided by RGD
    Official Full Name
    caspase 8 associated protein 2provided by RGD
    Primary source
    RGD:1305771
    See related
    EnsemblRapid:ENSRNOG00000006487 AllianceGenome:RGD:1305771
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including SUMO polymer binding activity; cysteine-type endopeptidase activator activity involved in apoptotic process; and identical protein binding activity. Predicted to be involved in Fas signaling pathway; cellular response to mechanical stimulus; and extrinsic apoptotic signaling pathway via death domain receptors. Predicted to act upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process. Located in cytoplasm and nucleus. Orthologous to human CASP8AP2 (caspase 8 associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 148.0), Spleen (RPKM 121.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Casp8ap2 in Genome Data Viewer
    Location:
    5q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (51809366..51848633)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (47014501..47052276)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (47853699..47891147)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102849 Neighboring gene BTB domain and CNC homolog 2 Neighboring gene uncharacterized LOC120102851 Neighboring gene gap junction protein, alpha 10 Neighboring gene midasin AAA ATPase 1 Neighboring gene LYR motif containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The microRNA-210/Casp8ap2 Axis Alleviates Hypoxia-Induced Myocardial Injury by Regulating Apoptosis and Autophagy. Wu TY, et al. Cytogenet Genome Res, 2021. PMID 33882492
    2. Protection of Human Umbilical Vein Endothelial Cells against Oxidative Stress by MicroRNA-210. Li T, et al. Oxid Med Cell Longev, 2017. PMID 28367268, Free PMC Article
    3. The MicroRNA-210/Casp8ap2 Pathway Alleviates Hypoxia-Induced Injury in Myocardial Cells by Regulating Apoptosis and Autophagy. Li K, et al. Heart Surg Forum, 2020 Oct 21. PMID 33234216
    4. Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators. Kino T, et al. J Biol Chem, 2003 Jan 31. PMID 12477726
    5. Concomitant activation of miR-107/PDCD10 and hypoxamir-210/Casp8ap2 and their role in cytoprotection during ischemic preconditioning of stem cells. Kim HW, et al. Antioxid Redox Signal, 2012 Oct 15. PMID 22482882, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The microRNA-210/Casp8ap2 Axis Alleviates Hypoxia-Induced Myocardial Injury by Regulating Apoptosis and Autophagy.
      Title: The microRNA-210/Casp8ap2 Axis Alleviates Hypoxia-Induced Myocardial Injury by Regulating Apoptosis and Autophagy.
    2. The MicroRNA-210/Casp8ap2 Pathway Alleviates Hypoxia-Induced Injury in Myocardial Cells by Regulating Apoptosis and Autophagy.
      Title: The MicroRNA-210/Casp8ap2 Pathway Alleviates Hypoxia-Induced Injury in Myocardial Cells by Regulating Apoptosis and Autophagy.
    3. The ischemic preconditioning (IPC) enhances stem cell survival via the combined participation of hypoxia responsive miRs miR-107 and miR-210 via their respective putative target genes Pdcd10 and Casp8ap2.
      Title: Concomitant activation of miR-107/PDCD10 and hypoxamir-210/Casp8ap2 and their role in cytoprotection during ischemic preconditioning of stem cells.
    4. Data identified FLICE-associated huge protein (FLASH)/caspase-8-associated protein-2 (Casp8ap2) in (PC)MSCs as the target gene of miR-210.
      Title: Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SUMO polymer binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type endopeptidase activator activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Fas signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Fas signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extrinsic apoptotic signaling pathway via death domain receptors IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CASP8-associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107921.1 → NP_001101391.1  CASP8-associated protein 2

      See identical proteins and their annotated locations for NP_001101391.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473962
      UniProtKB/TrEMBL
      A6IIJ5, D4A7V6
      Related
      ENSRNOP00000009227.4, ENSRNOT00000009228.8
      Conserved Domains (2) summary
      cd12202
      Location:1896 → 1960
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      cl23720
      Location:70 → 142
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      51809366..51848633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237975.5 → XP_006238037.1  CASP8-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006238037.1

      UniProtKB/TrEMBL
      A6IIJ5, D4A7V6
      Conserved Domains (2) summary
      cd12202
      Location:1896 → 1960
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      cl23720
      Location:70 → 142
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. XM_006237973.5 → XP_006238035.1  CASP8-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006238035.1

      UniProtKB/TrEMBL
      A6IIJ5, D4A7V6
      Related
      ENSRNOP00000103253.1, ENSRNOT00000153566.1
      Conserved Domains (2) summary
      cd12202
      Location:1896 → 1960
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      cl23720
      Location:70 → 142
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    3. XM_006237974.4 → XP_006238036.1  CASP8-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006238036.1

      UniProtKB/TrEMBL
      A6IIJ5, D4A7V6
      Conserved Domains (2) summary
      cd12202
      Location:1896 → 1960
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      cl23720
      Location:70 → 142
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein Strain
    Heading Accession and Version

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