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    Uck2 uridine-cytidine kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304944, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Uck2provided by RGD
    Official Full Name
    uridine-cytidine kinase 2provided by RGD
    Primary source
    RGD:620742
    See related
    EnsemblRapid:ENSRNOG00000003917 AllianceGenome:RGD:620742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Umpk
    Summary
    Predicted to enable cytidine kinase activity; identical protein binding activity; and uridine kinase activity. Involved in cellular response to oxygen levels; feeding behavior; and response to axon injury. Predicted to be active in cytoplasm. Orthologous to human UCK2 (uridine-cytidine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 118.5), Heart (RPKM 80.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uck2 in Genome Data Viewer
    Location:
    13q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (81913732..81971036, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (79380807..79438121, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (85376716..85443976, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29, pseudogene 20 Neighboring gene small nucleolar RNA U13 Neighboring gene transmembrane and coiled-coil domains 1 Neighboring gene aldehyde dehydrogenase 9 family, member A1 Neighboring gene NOP10 ribonucleoprotein like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sensitivity of human cancer cells to the new anticancer ribo-nucleoside TAS-106 is correlated with expression of uridine-cytidine kinase 2. Shimamoto Y, et al. Jpn J Cancer Res, 2002 Jul. PMID 12149149, Free PMC Article
    2. Postnatal ontogeny of uridine kinase in the cerebellum, hypothalamus, and cerebral cortex of the rat. Litteria M, et al. Neurochem Res, 1985 Jan. PMID 2984595
    3. Adverse effects of hyperbaric oxygen on [3H]uridine incorporation and uridine kinase activity in B104 rat neuroblastoma cells. Gendimenico GJ, et al. Mol Cell Biochem, 1990 Jun 1. PMID 2164139
    4. Effect of diabetes and fasting on the uridine triphosphate content and uridine kinase activity of rat cardiac and skeletal muscle. Gertz BJ, et al. Metabolism, 1979 Apr. PMID 221781
    5. Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase. Suzuki NN, et al. Structure, 2004 May. PMID 15130468

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytidine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytidine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables uridine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in CMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CTP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CTP salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in CTP salvage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in UMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UMP salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UMP salvage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to oxygen levels IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in feeding behavior IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in protein deubiquitination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to axon injury IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uridine-cytidine kinase 2
    Names
    UCK 2
    cytidine monophosphokinase 2
    uridine monophosphate kinase
    uridine monophosphokinase 2
    NP_001402675.1
    XP_038946718.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415746.1 → NP_001402675.1  uridine-cytidine kinase 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      B2RZ83, Q9QYG8
      UniProtKB/TrEMBL
      A0A0G2JX05
      Related
      ENSRNOP00000068308.2, ENSRNOT00000076125.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      81913732..81971036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090790.2 → XP_038946718.1  uridine-cytidine kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AI33
      Related
      ENSRNOP00000095493.2, ENSRNOT00000098075.2
      Conserved Domains (1) summary
      cd02023
      Location:38 → 234
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001102408.2: Suppressed sequence

      Description
      NM_001102408.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYG8.2 GenPept UniProtKB/Swiss-Prot:Q9QYG8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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