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    Tgm4 transglutaminase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64679, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tgm4provided by RGD
    Official Full Name
    transglutaminase 4provided by RGD
    Primary source
    RGD:620785
    See related
    EnsemblRapid:ENSRNOG00000004320 AllianceGenome:RGD:620785
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dp1
    Summary
    Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in peptide cross-linking. Predicted to act upstream of or within mating plug formation. Predicted to be located in Golgi apparatus. Predicted to be active in collagen-containing extracellular matrix. Orthologous to human TGM4 (transglutaminase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 36.2), Kidney (RPKM 24.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tgm4 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (131566887..131603920)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (122689429..122726463)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (132117279..132157485)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene similar to RIKEN cDNA 1110059G10 Neighboring gene kinesin family member 15 Neighboring gene transmembrane protein 42 Neighboring gene zinc finger DHHC-type palmitoyltransferase 3 Neighboring gene exosome component 7 Neighboring gene C-type lectin domain family 3, member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Androgen regulated prostate genes: structural analysis and regulation. Ho KC, et al. Prog Clin Biol Res, 1987. PMID 3309953
    2. Molecular cloning of rat prostate transglutaminase complementary DNA. The major androgen-regulated protein DP1 of rat dorsal prostate and coagulating gland. Ho KC, et al. J Biol Chem, 1992 Jun 25. PMID 1352290
    3. Genetic disruption of the copulatory plug in mice leads to severely reduced fertility. Dean MD. PLoS Genet, 2013. PMID 23341775, Free PMC Article
    4. Monoclonal antibodies to human transglutaminase 4. Cho SY, et al. Hybridoma (Larchmt), 2010 Jun. PMID 20569004
    5. The prostate transglutaminase, TGase-4, coordinates with the HGFL/MSP-RON system in stimulating the migration of prostate cancer cells. Jiang WG, et al. Int J Oncol, 2010 Aug. PMID 20596668

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mating plug formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein-glutamine gamma-glutamyltransferase 4
    Names
    TGase-4
    dorsal prostate transglutaminase
    dorsal protein 1
    glutamine gamma-glutamyltransferase 4
    transglutaminase 4 (prostate)
    NP_073204.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022713.2 → NP_073204.2  protein-glutamine gamma-glutamyltransferase 4

      See identical proteins and their annotated locations for NP_073204.2

      Status: VALIDATED

      Source sequence(s)
      BC066665, CA339697, DN931716, DN934649
      UniProtKB/Swiss-Prot
      Q6NYB5, Q99041
      UniProtKB/TrEMBL
      A6I4A2, Z4YP11
      Related
      ENSRNOP00000052677.4, ENSRNOT00000055822.5
      Conserved Domains (4) summary
      smart00460
      Location:249 → 341
      TGc; Transglutaminase/protease-like homologues
      COG1305
      Location:252 → 373
      YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
      pfam00868
      Location:8 → 116
      Transglut_N; Transglutaminase family
      pfam00927
      Location:571 → 667
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      131566887..131603920
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99041.2 GenPept UniProtKB/Swiss-Prot:Q99041

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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