Matn4 matrilin 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Matn4provided by RGD
Official Full Name: matrilin 4provided by RGD
Primary source: RGD:1309732
See related: EnsemblRapid:ENSRNOG00000014021 AllianceGenome:RGD:1309732
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium ion binding activity. Predicted to act upstream of or within response to axon injury. Predicted to be part of matrilin complex. Predicted to be active in collagen-containing extracellular matrix. Orthologous to human MATN4 (matrilin 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 69.2), Brain (RPKM 12.2) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (173539966..173554984, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (153120605..153135628, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (160838632..160853650, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D3Got140 (e-PCR)
- UniSTS:112047

AJ006140 (e-PCR)
- UniSTS:163304

RH143189 (e-PCR)
- UniSTS:232436

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to axon injury	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of matrilin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: matrilin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106539.1 → NP_001100009.1 matrilin-4 precursor

See identical proteins and their annotated locations for NP_001100009.1

Status: PROVISIONAL

Source sequence(s)

CH474005

UniProtKB/TrEMBL

A6JX80, D3ZMS3

Related

ENSRNOP00000018844.7, ENSRNOT00000018844.8

Conserved Domains (3) summary

cd01475
Location:33 → 255

vWA_Matrilin; VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. ...

pfam14670
Location:262 → 297

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:385 → 621

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...