Slc38a9 solute carrier family 38, member 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc38a9provided by RGD
Official Full Name: solute carrier family 38, member 9provided by RGD
Primary source: RGD:1311881
See related: EnsemblRapid:ENSRNOG00000009851 AllianceGenome:RGD:1311881
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311881
Summary: Predicted to enable several functions, including L-amino acid transmembrane transporter activity; arginine binding activity; and cholesterol binding activity. Predicted to be involved in carboxylic acid transport; cellular response to amino acid stimulus; and positive regulation of TORC1 signaling. Predicted to be located in late endosome and lysosome. Predicted to be part of FNIP-folliculin RagC/D GAP and Ragulator complex. Predicted to be active in lysosomal membrane. Orthologous to human SLC38A9 (solute carrier family 38 member 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 62.3), Thymus (RPKM 56.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q14

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (46024731..46102419)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (44291637..44374897)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (44512556..44592793)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-arginine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-arginine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-asparagine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-asparagine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-glutamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-glutamine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-leucine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables active monoatomic ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables arginine binding	ISS Inferred from Sequence or Structural Similarity more info
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables cholesterol binding	ISS Inferred from Sequence or Structural Similarity more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables inorganic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables secondary active transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables sterol sensor activity	ISO Inferred from Sequence Orthology more info
enables sterol sensor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-arginine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-arginine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in amino acid transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in asparagine transport	ISO Inferred from Sequence Orthology more info
involved_in asparagine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in branched-chain amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutamine transport	ISO Inferred from Sequence Orthology more info
involved_in glutamine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in inorganic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of FNIP-folliculin RagC/D GAP	ISO Inferred from Sequence Orthology more info
part_of Ragulator complex	ISO Inferred from Sequence Orthology more info
part_of Ragulator complex	ISS Inferred from Sequence or Structural Similarity more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: neutral amino acid transporter 9

Names: putative sodium-coupled neutral amino acid transporter 9; sodium-coupled neutral amino acid transporter 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001035251.1 → NP_001030328.1 neutral amino acid transporter 9

See identical proteins and their annotated locations for NP_001030328.1

Status: PROVISIONAL

Source sequence(s)

BC105869

UniProtKB/Swiss-Prot

Q3B8Q3, Q561Z8, R9PXU2

UniProtKB/TrEMBL

A6I5P6, H9BFG3

Conserved Domains (1) summary

cl00456
Location:114 → 555

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

46024731..46102419

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281731.1 → XP_063137801.1 neutral amino acid transporter 9 isoform X1

UniProtKB/Swiss-Prot

Q3B8Q3, Q561Z8, R9PXU2

UniProtKB/TrEMBL

A6I5P6, H9BFG3
XM_006231929.5 → XP_006231991.1 neutral amino acid transporter 9 isoform X1

See identical proteins and their annotated locations for XP_006231991.1

UniProtKB/Swiss-Prot

Q3B8Q3, Q561Z8, R9PXU2

UniProtKB/TrEMBL

A6I5P6, H9BFG3

Conserved Domains (1) summary

cl00456
Location:114 → 555

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006231930.5 → XP_006231992.1 neutral amino acid transporter 9 isoform X1

See identical proteins and their annotated locations for XP_006231992.1

UniProtKB/Swiss-Prot

Q3B8Q3, Q561Z8, R9PXU2

UniProtKB/TrEMBL

A6I5P6, H9BFG3

Related

ENSRNOP00000099743.1, ENSRNOT00000132035.1

Conserved Domains (1) summary

cl00456
Location:114 → 555

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006231931.5 → XP_006231993.1 neutral amino acid transporter 9 isoform X1

See identical proteins and their annotated locations for XP_006231993.1

UniProtKB/Swiss-Prot

Q3B8Q3, Q561Z8, R9PXU2

UniProtKB/TrEMBL

A6I5P6, H9BFG3

Conserved Domains (1) summary

cl00456
Location:114 → 555

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_063281732.1 → XP_063137802.1 neutral amino acid transporter 9 isoform X3

UniProtKB/TrEMBL

A6I5P7
XM_063281733.1 → XP_063137803.1 neutral amino acid transporter 9 isoform X3

UniProtKB/TrEMBL

A6I5P7
XM_006231937.5 → XP_006231999.1 neutral amino acid transporter 9 isoform X3

See identical proteins and their annotated locations for XP_006231999.1

UniProtKB/TrEMBL

A6I5P7

Conserved Domains (2) summary

COG0814
Location:53 → 497

SdaC; Amino acid permease [Amino acid transport and metabolism]

cl00456
Location:52 → 493

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006231934.4 → XP_006231996.1 neutral amino acid transporter 9 isoform X2

UniProtKB/TrEMBL

A6I5P7

Related

ENSRNOP00000013218.7, ENSRNOT00000013218.8

Conserved Domains (2) summary

COG0814
Location:83 → 527

SdaC; Amino acid permease [Amino acid transport and metabolism]

cl00456
Location:82 → 523

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_063281735.1 → XP_063137805.1 neutral amino acid transporter 9 isoform X3

UniProtKB/TrEMBL

A6I5P7
XM_063281734.1 → XP_063137804.1 neutral amino acid transporter 9 isoform X3

UniProtKB/TrEMBL

A6I5P7
XM_006231936.4 → XP_006231998.1 neutral amino acid transporter 9 isoform X3

See identical proteins and their annotated locations for XP_006231998.1

UniProtKB/TrEMBL

A6I5P7

Conserved Domains (2) summary

COG0814
Location:53 → 497

SdaC; Amino acid permease [Amino acid transport and metabolism]

cl00456
Location:52 → 493

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006231939.5 → XP_006232001.1 neutral amino acid transporter 9 isoform X3

See identical proteins and their annotated locations for XP_006232001.1

UniProtKB/TrEMBL

A6I5P7

Conserved Domains (2) summary

COG0814
Location:53 → 497

SdaC; Amino acid permease [Amino acid transport and metabolism]

cl00456
Location:52 → 493

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006231932.4 → XP_006231994.1 neutral amino acid transporter 9 isoform X1

See identical proteins and their annotated locations for XP_006231994.1

UniProtKB/Swiss-Prot

Q3B8Q3, Q561Z8, R9PXU2

UniProtKB/TrEMBL

A6I5P6, H9BFG3

Conserved Domains (1) summary

cl00456
Location:114 → 555

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain