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    Eya4 EYA transcriptional coactivator and phosphatase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292172, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eya4provided by RGD
    Official Full Name
    EYA transcriptional coactivator and phosphatase 4provided by RGD
    Primary source
    RGD:1307099
    See related
    EnsemblRapid:ENSRNOG00000016627 AllianceGenome:RGD:1307099
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Involved in inner ear development. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 10; congestive heart failure; dilated cardiomyopathy; dilated cardiomyopathy 1J; and sensorineural hearing loss. Orthologous to human EYA4 (EYA transcriptional coactivator and phosphatase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 118.6), Muscle (RPKM 68.5) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eya4 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (23991431..24235132)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (22172275..22415978)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (23237617..23611580)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349443 Neighboring gene uncharacterized LOC102554376 Neighboring gene uncharacterized LOC134482584 Neighboring gene uncharacterized LOC120098871 Neighboring gene uncharacterized LOC102555465 Neighboring gene transcription factor 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus. Wayne S, et al. Hum Mol Genet, 2001 Feb 1. PMID 11159937
    2. Eya4 Induces Hypertrophy via Regulation of p27kip1. Williams T, et al. Circ Cardiovasc Genet, 2015 Dec. PMID 26499333
    3. Eya4-deficient mice are a model for heritable otitis media. Depreux FF, et al. J Clin Invest, 2008 Feb. PMID 18219393, Free PMC Article
    4. Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss. Schönberger J, et al. Nat Genet, 2005 Apr. PMID 15735644
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inner ear development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within middle ear morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eyes absent homolog 4
    NP_001258246.1
    XP_038959232.1
    XP_038959234.1
    XP_038959236.1
    XP_038959239.1
    XP_038959240.1
    XP_038959241.1
    XP_038959243.1
    XP_038959244.1
    XP_038959249.1
    XP_038959259.1
    XP_038959263.1
    XP_038959266.1
    XP_063138895.1
    XP_063138896.1
    XP_063138897.1
    XP_063138898.1
    XP_063138901.1
    XP_063138902.1
    XP_063138903.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271317.1 → NP_001258246.1  eyes absent homolog 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6B402, A6JUP2
      Related
      ENSRNOP00000022362.8, ENSRNOT00000022362.9
      Conserved Domains (2) summary
      PTZ00395
      Location:139 → 318
      PTZ00395; Sec24-related protein; Provisional
      cd02601
      Location:345 → 616
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      23991431..24235132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103304.2 → XP_038959232.1  eyes absent homolog 4 isoform X3

      UniProtKB/TrEMBL
      A6JUP2
      Conserved Domains (2) summary
      PTZ00395
      Location:162 → 341
      PTZ00395; Sec24-related protein; Provisional
      cd02601
      Location:368 → 639
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

    2. XM_039103308.2 → XP_038959236.1  eyes absent homolog 4 isoform X2

      UniProtKB/TrEMBL
      A6JUP2, F1LX86
      Related
      ENSRNOP00000097961.2, ENSRNOT00000113193.2
      Conserved Domains (2) summary
      PTZ00395
      Location:162 → 341
      PTZ00395; Sec24-related protein; Provisional
      cd02601
      Location:368 → 639
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

    3. XM_039103311.2 → XP_038959239.1  eyes absent homolog 4 isoform X4

      UniProtKB/TrEMBL
      A6JUP2
      Conserved Domains (2) summary
      PTZ00395
      Location:157 → 336
      PTZ00395; Sec24-related protein; Provisional
      cd02601
      Location:363 → 634
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

    4. XM_039103312.2 → XP_038959240.1  eyes absent homolog 4 isoform X5

      UniProtKB/TrEMBL
      A0A8I6B402, A6JUP2
      Conserved Domains (2) summary
      PTZ00395
      Location:139 → 318
      PTZ00395; Sec24-related protein; Provisional
      cd02601
      Location:345 → 616
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

    5. XM_039103313.2 → XP_038959241.1  eyes absent homolog 4 isoform X6

      UniProtKB/TrEMBL
      A6JUP2
      Related
      ENSRNOP00000096314.2, ENSRNOT00000116083.2
      Conserved Domains (2) summary
      PTZ00395
      Location:139 → 318
      PTZ00395; Sec24-related protein; Provisional
      cd02601
      Location:345 → 616
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

    6. XM_039103315.2 → XP_038959243.1  eyes absent homolog 4 isoform X8

      UniProtKB/TrEMBL
      A6JUP2
      Conserved Domains (2) summary
      PTZ00395
      Location:134 → 313
      PTZ00395; Sec24-related protein; Provisional
      cd02601
      Location:340 → 611
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

    7. XM_039103316.2 → XP_038959244.1  eyes absent homolog 4 isoform X11

      UniProtKB/TrEMBL
      A0A8I6A7V1, A6JUP2
      Related
      ENSRNOP00000099830.1, ENSRNOT00000129366.1
      Conserved Domains (2) summary
      PTZ00395
      Location:108 → 287
      PTZ00395; Sec24-related protein; Provisional
      cd02601
      Location:314 → 585
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

    8. XM_039103338.2 → XP_038959266.1  eyes absent homolog 4 isoform X1

      UniProtKB/TrEMBL
      A6JUP2
      Related
      ENSRNOP00000089077.2, ENSRNOT00000102230.2
      Conserved Domains (2) summary
      PTZ00395
      Location:108 → 287
      PTZ00395; Sec24-related protein; Provisional
      cd02601
      Location:314 → 585
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

    9. XM_039103335.2 → XP_038959263.1  eyes absent homolog 4 isoform X17

      Conserved Domains (2) summary
      PTZ00395
      Location:162 → 341
      PTZ00395; Sec24-related protein; Provisional
      cl21460
      Location:368 → 446
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    10. XM_063282825.1 → XP_063138895.1  eyes absent homolog 4 isoform X7

      UniProtKB/TrEMBL
      A6JUP2

    11. XM_063282826.1 → XP_063138896.1  eyes absent homolog 4 isoform X9

      UniProtKB/TrEMBL
      A6JUP2
      Related
      ENSRNOP00000112543.1, ENSRNOT00000153564.1

    12. XM_063282827.1 → XP_063138897.1  eyes absent homolog 4 isoform X10

      UniProtKB/TrEMBL
      A6JUP2

    13. XM_039103306.2 → XP_038959234.1  eyes absent homolog 4 isoform X3

      UniProtKB/TrEMBL
      A6JUP2
      Conserved Domains (2) summary
      PTZ00395
      Location:162 → 341
      PTZ00395; Sec24-related protein; Provisional
      cd02601
      Location:368 → 639
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

    14. XM_063282828.1 → XP_063138898.1  eyes absent homolog 4 isoform X11

      UniProtKB/TrEMBL
      A0A8I6A7V1, A6JUP2

    15. XM_039103321.2 → XP_038959249.1  eyes absent homolog 4 isoform X12

      UniProtKB/TrEMBL
      A0A8I6AS60, A6JUP2
      Related
      ENSRNOP00000107060.1, ENSRNOT00000167396.1
      Conserved Domains (2) summary
      PTZ00395
      Location:81 → 260
      PTZ00395; Sec24-related protein; Provisional
      cd02601
      Location:287 → 558
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

    16. XM_063282831.1 → XP_063138901.1  eyes absent homolog 4 isoform X13

      UniProtKB/TrEMBL
      A6JUP2

    17. XM_063282832.1 → XP_063138902.1  eyes absent homolog 4 isoform X14

      UniProtKB/TrEMBL
      A6JUP2

    18. XM_039103331.2 → XP_038959259.1  eyes absent homolog 4 isoform X15

      UniProtKB/TrEMBL
      A6JUP2
      Conserved Domains (2) summary
      PTZ00395
      Location:50 → 229
      PTZ00395; Sec24-related protein; Provisional
      cd02601
      Location:256 → 527
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

    19. XM_063282833.1 → XP_063138903.1  eyes absent homolog 4 isoform X16

    Nucleotide Protein Strain
    Heading Accession and Version

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