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    Kdsr 3-ketodihydrosphingosine reductase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360833, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kdsrprovided by RGD
    Official Full Name
    3-ketodihydrosphingosine reductaseprovided by RGD
    Primary source
    RGD:1307775
    See related
    EnsemblRapid:ENSRNOG00000002781 AllianceGenome:RGD:1307775
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fvt1
    Summary
    Predicted to enable 3-dehydrosphinganine reductase activity. Predicted to be involved in 3-keto-sphinganine metabolic process and sphingolipid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 4 and follicular lymphoma. Orthologous to human KDSR (3-ketodihydrosphingosine reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 161.9), Liver (RPKM 92.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kdsr in Genome Data Viewer
    Location:
    13p11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (23374101..23408779, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (22862117..22894118, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (26779386..26812271, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene BCL2, apoptosis regulator Neighboring gene uncharacterized LOC120096229 Neighboring gene uncharacterized LOC134481474 Neighboring gene uncharacterized LOC134481473 Neighboring gene vacuolar protein sorting 4 homolog B Neighboring gene serpin family B member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FVT-1, a novel human transcription unit affected by variant translocation t(2;18)(p11;q21) of follicular lymphoma. Rimokh R, et al. Blood, 1993 Jan 1. PMID 8417785
    2. Mutations in KDSR Cause Recessive Progressive Symmetric Erythrokeratoderma. Boyden LM, et al. Am J Hum Genet, 2017 Jun 1. PMID 28575652, Free PMC Article
    3. FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane. Kihara A, et al. J Biol Chem, 2004 Nov 19. PMID 15328338
    4. Lateral diffusion of inositol 1,4,5-trisphosphate receptor type 1 is regulated by actin filaments and 4.1N in neuronal dendrites. Fukatsu K, et al. J Biol Chem, 2004 Nov 19. PMID 15364918
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-dehydrosphinganine reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-dehydrosphinganine reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3-keto-sphinganine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within 3-keto-sphinganine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in 3-keto-sphinganine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sphingolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sphingolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    3-ketodihydrosphingosine reductase
    Names
    follicular lymphoma variant translocation 1
    NP_001101812.1
    XP_038946804.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108342.1 → NP_001101812.1  3-ketodihydrosphingosine reductase

      See identical proteins and their annotated locations for NP_001101812.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474000
      UniProtKB/TrEMBL
      A0A8I6AMK1, A6JSU9, A6JSV0
      Related
      ENSRNOP00000085720.1, ENSRNOT00000099177.2
      Conserved Domains (1) summary
      cd08939
      Location:32 → 268
      KDSR-like_SDR_c; 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      23374101..23408779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090876.2 → XP_038946804.1  3-ketodihydrosphingosine reductase isoform X1

      UniProtKB/TrEMBL
      A6JSU9, D3Z9P1
      Related
      ENSRNOP00000093847.2, ENSRNOT00000099271.2
      Conserved Domains (1) summary
      cd08939
      Location:32 → 258
      KDSR-like_SDR_c; 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR
    Nucleotide Protein Strain
    Heading Accession and Version

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