Dhcr24 24-dehydrocholesterol reductase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dhcr24provided by RGD
Official Full Name: 24-dehydrocholesterol reductaseprovided by RGD
Primary source: RGD:1306529
See related: EnsemblRapid:ENSRNOG00000006787 AllianceGenome:RGD:1306529
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable enzyme binding activity; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; and peptide antigen binding activity. Involved in several processes, including Ras protein signal transduction; negative regulation of cell population proliferation; and steroid metabolic process. Predicted to be located in endoplasmic reticulum and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in lipid metabolism disorder. Orthologous to human DHCR24 (24-dehydrocholesterol reductase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 861.2), Brain (RPKM 226.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q34

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (126573366..126599940)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (121344552..121371124)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (126164708..126188926)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein disulfide isomerase A3 might be involved in the regulation of 24-dehydrocholesterol reductase via vitamin D equilibrium in primary cortical neurons.
Title: Protein disulfide isomerase A3 might be involved in the regulation of 24-dehydrocholesterol reductase via vitamin D equilibrium in primary cortical neurons.
Data suggest that expression of Dhcr24 is up-/down-regulated in rat striatal precursor cell line during oxidative stress depending on co-expression level of wild-type/mutant human huntingtin.
Title: Altered expression of 3-betahydroxysterol delta-24-reductase/selective Alzheimer's disease indicator-1 gene in Huntington's disease models.
Expression of the seladin-1 gene (DHCR24) on days 9, 10, and 11 may contribute to the development of hair follicle stem cells.
Title: Neuronal differentiation of rat hair follicle stem cells: the involvement of the neuroprotective factor Seladin-1 (DHCR24).
seladin-1 expression and intracellular localization are correlated with both the intensity and nature of ACTH-induced steroidogenesis and resultant oxidative stress.
Title: 24-dehydrocholesterol reductase/seladin-1: a key protein differentially involved in adrenocorticotropin effects observed in human and rat adrenal cortex.
identification, using a direct genetic screen, Seladin-1 (also known as Dhcr24) as a key mediator of Ras-induced senescence
Title: Regulation of cellular response to oncogenic and oxidative stress by Seladin-1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129232 (e-PCR)
- UniSTS:212540

RH129237 (e-PCR)
- UniSTS:212545

RH129686 (e-PCR)
- UniSTS:212545

RH128821 (e-PCR)
- UniSTS:212129

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables delta24(24-1) sterol reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables delta24(24-1) sterol reductase activity	ISO Inferred from Sequence Orthology more info
enables delta24-sterol reductase activity	IC Inferred by Curator more info	PubMed
enables delta24-sterol reductase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	NAS Non-traceable Author Statement more info	PubMed
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	ISO Inferred from Sequence Orthology more info
enables peptide antigen binding	ISO Inferred from Sequence Orthology more info
enables peptide antigen binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cholesterol biosynthetic process via desmosterol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male genitalia development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within membrane organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plasminogen activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in skin development	ISO Inferred from Sequence Orthology more info
involved_in skin development	ISS Inferred from Sequence or Structural Similarity more info
involved_in steroid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tissue development	ISO Inferred from Sequence Orthology more info
involved_in tissue development	ISO Inferred from Sequence Orthology more info
involved_in tissue development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: delta(24)-sterol reductase

Names: 3-beta-hydroxysterol delta-24-reductase; seladin-1

NP_001073617.2

EC 1.3.1.72

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.