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    Arhgef3 Rho guanine nucleotide exchange factor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290541, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arhgef3provided by RGD
    Official Full Name
    Rho guanine nucleotide exchange factor 3provided by RGD
    Primary source
    RGD:1310672
    See related
    EnsemblRapid:ENSRNOG00000014363 AllianceGenome:RGD:1310672
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of Rho protein signal transduction. Predicted to be located in cytoplasm. Orthologous to human ARHGEF3 (Rho guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 192.1), Spleen (RPKM 176.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgef3 in Genome Data Viewer
    Location:
    16p16
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (2308311..2588634)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (2301573..2581951)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (2743714..3026768)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097513 Neighboring gene HESX homeobox 1 Neighboring gene interleukin 17 receptor D Neighboring gene uncharacterized LOC102548056 Neighboring gene uncharacterized LOC134482440 Neighboring gene transcription activation suppressor Neighboring gene coiled-coil domain containing 66 Neighboring gene MLV-related proviral Env polyprotein-like, pseudogene 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 3
    Names
    Rho guanine nucleotide exchange factor (GEF) 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106061.1 → NP_001099531.1  rho guanine nucleotide exchange factor 3

      See identical proteins and their annotated locations for NP_001099531.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474067
      UniProtKB/TrEMBL
      A0A8I6GK05, A6KMK9, D4A1J1
      Related
      ENSRNOP00000019511.4, ENSRNOT00000019511.7
      Conserved Domains (2) summary
      cd10572
      Location:315 → 447
      PH_RhoGEF3_XPLN; Rho guanine nucleotide exchange factor 3 Pleckstrin homology (PH) domain
      pfam00621
      Location:125 → 301
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      2308311..2588634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600023.3 → XP_017455512.1  rho guanine nucleotide exchange factor 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYL3, A0A8I6GK05
      Conserved Domains (2) summary
      cd10572
      Location:342 → 474
      PH_RhoGEF3_XPLN; Rho guanine nucleotide exchange factor 3 Pleckstrin homology (PH) domain
      pfam00621
      Location:152 → 328
      RhoGEF; RhoGEF domain

    2. XM_006252575.5 → XP_006252637.1  rho guanine nucleotide exchange factor 3 isoform X1

      See identical proteins and their annotated locations for XP_006252637.1

      UniProtKB/TrEMBL
      A0A0G2JYL3, A0A8I6GK05
      Conserved Domains (2) summary
      cd10572
      Location:342 → 474
      PH_RhoGEF3_XPLN; Rho guanine nucleotide exchange factor 3 Pleckstrin homology (PH) domain
      pfam00621
      Location:152 → 328
      RhoGEF; RhoGEF domain

    3. XM_006252574.5 → XP_006252636.1  rho guanine nucleotide exchange factor 3 isoform X1

      See identical proteins and their annotated locations for XP_006252636.1

      UniProtKB/TrEMBL
      A0A0G2JYL3, A0A8I6GK05
      Related
      ENSRNOP00000095441.2, ENSRNOT00000101017.2
      Conserved Domains (2) summary
      cd10572
      Location:342 → 474
      PH_RhoGEF3_XPLN; Rho guanine nucleotide exchange factor 3 Pleckstrin homology (PH) domain
      pfam00621
      Location:152 → 328
      RhoGEF; RhoGEF domain

    4. XM_006252576.5 → XP_006252638.1  rho guanine nucleotide exchange factor 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A424, A0A8I6GK05
      Related
      ENSRNOP00000086642.1, ENSRNOT00000096646.2
      Conserved Domains (2) summary
      cd10572
      Location:322 → 454
      PH_RhoGEF3_XPLN; Rho guanine nucleotide exchange factor 3 Pleckstrin homology (PH) domain
      pfam00621
      Location:132 → 308
      RhoGEF; RhoGEF domain

    5. XM_017600022.3 → XP_017455511.1  rho guanine nucleotide exchange factor 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GK05, A0A8I6GMI2
      Related
      ENSRNOP00000097424.1, ENSRNOT00000119297.2
    Nucleotide Protein Strain
    Heading Accession and Version

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