Tox2 TOX high mobility group box family member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tox2provided by RGD
Official Full Name: TOX high mobility group box family member 2provided by RGD
Primary source: RGD:735184
See related: EnsemblRapid:ENSRNOG00000008146 AllianceGenome:RGD:735184
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gcx1; GCX-1
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in female gonad development; positive regulation of transcription by RNA polymerase II; and response to gonadotropin. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human TOX2 (TOX high mobility group box family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 6.4), Lung (RPKM 5.8) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (172272718..172400235)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (151853294..151980086)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (159569329..159694756)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data strongly suggest that granulosa cell HMG-box protein-1(GCX-1) is a novel transcriptional activator that is expressed in reproductive tissues involving the hypothalamo-pituitary-gonadal axis, and functions as a regulator of follicular development
Title: Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells.

Submit: New GeneRIF Correction

General gene information

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Markers

Tox2 (e-PCR), detects polymorphism
- UniSTS:536676

Tox2 (e-PCR), detects polymorphism
- UniSTS:536677

Tox2 (e-PCR), detects polymorphism
- UniSTS:536678

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in female gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to gonadotropin	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TOX high mobility group box family member 2

Names: granulosa cell HMG box protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199392.2 → NP_955424.2 TOX high mobility group box family member 2

Status: VALIDATED

Source sequence(s)

AB096685

UniProtKB/TrEMBL

A0A8I6G6H2

Related

ENSRNOP00000061248.3, ENSRNOT00000064159.3

Conserved Domains (1) summary

cd00084
Location:246 → 311

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

172272718..172400235

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006235578.5 → XP_006235640.1 TOX high mobility group box family member 2 isoform X1

UniProtKB/TrEMBL

A0A8I6A4F5, A0A8I6G6H2

Conserved Domains (1) summary

cd00084
Location:246 → 311

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
XM_039105121.2 → XP_038961049.1 TOX high mobility group box family member 2 isoform X4

Conserved Domains (1) summary

cd00084
Location:292 → 357

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
XM_063283868.1 → XP_063139938.1 TOX high mobility group box family member 2 isoform X3

UniProtKB/TrEMBL

A0A8I6G6H2
XM_039105118.2 → XP_038961046.1 TOX high mobility group box family member 2 isoform X2

UniProtKB/Swiss-Prot

Q76IQ7

UniProtKB/TrEMBL

A0A8I6G6H2

Conserved Domains (1) summary

cd00084
Location:204 → 269

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
XM_017591794.3 → XP_017447283.1 TOX high mobility group box family member 2 isoform X2

UniProtKB/Swiss-Prot

Q76IQ7

UniProtKB/TrEMBL

A0A8I6G6H2

Related

ENSRNOP00000109615.1, ENSRNOT00000139569.1

Conserved Domains (1) summary

cd00084
Location:204 → 269

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
XM_039105119.2 → XP_038961047.1 TOX high mobility group box family member 2 isoform X2

UniProtKB/Swiss-Prot

Q76IQ7

UniProtKB/TrEMBL

A0A8I6G6H2

Conserved Domains (1) summary

cd00084
Location:204 → 269

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
XM_039105120.2 → XP_038961048.1 TOX high mobility group box family member 2 isoform X2

UniProtKB/Swiss-Prot

Q76IQ7

UniProtKB/TrEMBL

A0A8I6G6H2

Conserved Domains (1) summary

cd00084
Location:204 → 269

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...