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    Neurl4 neuralized E3 ubiquitin protein ligase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303248, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Neurl4provided by RGD
    Official Full Name
    neuralized E3 ubiquitin protein ligase 4provided by RGD
    Primary source
    RGD:1308056
    See related
    EnsemblRapid:ENSRNOG00000016109 AllianceGenome:RGD:1308056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gps2l
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to act upstream of or within mitochondrial DNA repair and spermatogenesis. Predicted to be located in mitochondrion. Orthologous to human NEURL4 (neuralized E3 ubiquitin protein ligase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 118.8), Brain (RPKM 84.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Neurl4 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55123471..55135971)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54624923..54637262)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56511861..56524233)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 2 like 1 Neighboring gene G protein pathway suppressor 2 Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene Y box binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mitochondrial DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neuralized-like protein 4
    Names
    neuralized homolog 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107013.2 → NP_001100483.1  neuralized-like protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001100483.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6GKM4, A6HFW0
      Conserved Domains (2) summary
      smart00588
      Location:318 → 439
      NEUZ; domain in neuralized proteins
      cd12887
      Location:720 → 882
      SPRY_NHR_like; SPRY domain in neuralized homology repeat

    2. NM_001414351.1 → NP_001401280.1  neuralized-like protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6GKM4, D4A198
      Related
      ENSRNOP00000021883.6, ENSRNOT00000021883.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      55123471..55135971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269034.1 → XP_063125104.1  neuralized-like protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GKM4

    2. XM_039085986.2 → XP_038941914.1  neuralized-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9C7, A0A8I6GKM4
      Related
      ENSRNOP00000088223.1, ENSRNOT00000106054.2
      Conserved Domains (1) summary
      cd12887
      Location:503 → 664
      SPRY_NHR_like; SPRY domain in neuralized homology repeat

    3. XM_039085987.2 → XP_038941915.1  neuralized-like protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKM4
      Conserved Domains (1) summary
      cd12887
      Location:698 → 860
      SPRY_NHR_like; SPRY domain in neuralized homology repeat

    4. XM_039085988.2 → XP_038941916.1  neuralized-like protein 4 isoform X4

      Conserved Domains (1) summary
      cd12887
      Location:16 → 180
      SPRY_NHR_like; SPRY domain in neuralized homology repeat

    RNA

    1. XR_005489824.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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