Necab1 N-terminal EF-hand calcium binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Necab1provided by RGD
Official Full Name: N-terminal EF-hand calcium binding protein 1provided by RGD
Primary source: RGD:708548
See related: EnsemblRapid:ENSRNOG00000066027 AllianceGenome:RGD:708548
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Efcbp1; Stip-1
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in regulation of amyloid precursor protein biosynthetic process. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human NECAB1 (N-terminal EF-hand calcium binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 146.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q13

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (33155078..33375707, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (28357859..28578642, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (28507596..28737556, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Determines domain structure of the Necab 1 protein that expressed in the brain.
Title: NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern.

Submit: New GeneRIF Correction

General gene information

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Markers

RH141013 (e-PCR)
- UniSTS:223013

D8Got25 (e-PCR)
- UniSTS:113550

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in blastocyst hatching	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blastocyst hatching	ISO Inferred from Sequence Orthology more info
involved_in regulation of amyloid precursor protein biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: N-terminal EF-hand calcium-binding protein 1

Names: EF-hand calcium-binding protein 1; neuronal Ca(2+)-binding protein 1; neuronal calcium-binding protein 1; synaptotagmin interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022302.2 → NP_071638.1 N-terminal EF-hand calcium-binding protein 1

See identical proteins and their annotated locations for NP_071638.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q9ESB5

UniProtKB/TrEMBL

A0A8I6A6X8, A6IIA3

Related

ENSRNOP00000088635.2, ENSRNOT00000118373.2

Conserved Domains (3) summary

pfam03992
Location:254 → 325

ABM; Antibiotic biosynthesis monooxygenase

pfam13499
Location:33 → 89

EF-hand_7; EF-hand domain pair

cl08302
Location:31 → 87

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...