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    Ttc1 tetratricopeptide repeat domain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287208, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ttc1provided by RGD
    Official Full Name
    tetratricopeptide repeat domain 1provided by RGD
    Primary source
    RGD:1359604
    See related
    EnsemblRapid:ENSRNOG00000003980 AllianceGenome:RGD:1359604
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in cytosol. Orthologous to human TTC1 (tetratricopeptide repeat domain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 199.2), Heart (RPKM 182.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ttc1 in Genome Data Viewer
    Location:
    10q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (28703763..28728910, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (28202325..28227464, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (29342495..29367865, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2, pseudogene 35 Neighboring gene PWWP domain containing 2A Neighboring gene uncharacterized LOC108352076 Neighboring gene adrenoceptor alpha 1B Neighboring gene uncharacterized LOC134480677

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras. Marty C, et al. Mol Cell Biol, 2003 Jun. PMID 12748287, Free PMC Article
    2. A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity. Ligon LA, et al. J Biol Chem, 2004 Apr 30. PMID 14985359
    3. PEX14 is required for microtubule-based peroxisome motility in human cells. Bharti P, et al. J Cell Sci, 2011 May 15. PMID 21525035
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95276

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005529.1 → NP_001005529.1  tetratricopeptide repeat protein 1

      See identical proteins and their annotated locations for NP_001005529.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082093
      UniProtKB/TrEMBL
      A0A8I6AEL9, F7ER79, Q66H09
      Related
      ENSRNOP00000005304.3, ENSRNOT00000005304.7
      Conserved Domains (4) summary
      sd00006
      Location:119 → 144
      TPR; TPR repeat [structural motif]
      cd15830
      Location:126 → 244
      BamD; BamD lipoprotein, a component of the beta-barrel assembly machinery
      pfam00515
      Location:158 → 188
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:119 → 186
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      28703763..28728910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085372.2 → XP_038941300.1  tetratricopeptide repeat protein 1 isoform X1

      Conserved Domains (2) summary
      TIGR00990
      Location:116 → 212
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:119 → 144
      TPR; TPR repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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