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    Ddx19a DEAD-box helicase 19A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292022, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ddx19aprovided by RGD
    Official Full Name
    DEAD-box helicase 19Aprovided by RGD
    Primary source
    RGD:1303136
    See related
    EnsemblRapid:ENSRNOG00000018033 AllianceGenome:RGD:1303136
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ddx19; ZD10B
    Summary
    Predicted to enable ATP binding activity and hydrolase activity. Involved in positive regulation of apoptotic process and response to zinc ion. Orthologous to human DDX19A (DEAD-box helicase 19A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 566.8), Thymus (RPKM 158.3) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ddx19a in Genome Data Viewer
    Location:
    19q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (55851854..55872209, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (38942497..38962853, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (43251510..43271865)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483368 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Neighboring gene DEAD-box helicase 19B Neighboring gene alanyl-tRNA synthetase 1 Neighboring gene exosome component 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differentially expressed genes execute zinc-induced apoptosis in precancerous esophageal epithelium of zinc-deficient rats. Ishii H, et al. Oncogene, 2004 Oct 21. PMID 15361827
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase DDX19A
    Names
    DEAD (Asp-Glu-Ala-As) box polypeptide 19A
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 19
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 19a
    zinc responsive protein ZD10B
    NP_001005381.2
    XP_008770712.1
    XP_063134007.1
    XP_063134008.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005381.2 → NP_001005381.2  ATP-dependent RNA helicase DDX19A

      See identical proteins and their annotated locations for NP_001005381.2

      Status: VALIDATED

      Source sequence(s)
      BC079094, CB582878
      UniProtKB/TrEMBL
      A0A8J8Y6U2, F7DP80, Q68FX3
      Related
      ENSRNOP00000024793.9, ENSRNOT00000024793.9
      Conserved Domains (2) summary
      cd18787
      Location:306 → 442
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cl28899
      Location:74 → 302
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      55851854..55872209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277937.1 → XP_063134007.1  ATP-dependent RNA helicase DDX19A isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7X6

    2. XM_063277938.1 → XP_063134008.1  ATP-dependent RNA helicase DDX19A isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7X6

    3. XM_008772490.4 → XP_008770712.1  ATP-dependent RNA helicase DDX19A isoform X2

      UniProtKB/TrEMBL
      A0A0G2JY21
      Conserved Domains (2) summary
      cd18787
      Location:216 → 352
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cl28899
      Location:9 → 212
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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