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    Ubc ubiquitin C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50522, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ubcprovided by RGD
    Official Full Name
    ubiquitin Cprovided by RGD
    Primary source
    RGD:621244
    See related
    EnsemblRapid:ENSRNOG00000057823 AllianceGenome:RGD:621244
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in modification-dependent protein catabolic process and protein ubiquitination. Predicted to be located in mitochondrial outer membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBC (ubiquitin C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 29445.0), Kidney (RPKM 24271.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ubc in Genome Data Viewer
    Location:
    12q15
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (36899673..36905275)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (31239149..31243924)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (36638457..36642734)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene transfer RNA aspartic acid (anticodon GUC) 5 Neighboring gene transfer RNA alanine (anticodon UGC) 4 Neighboring gene igE-binding protein-like Neighboring gene scavenger receptor class B, member 1 Neighboring gene uncharacterized LOC134481291

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential ubiquitin-proteasome and autophagy signaling following rotator cuff tears and suprascapular nerve injury. Joshi SK, et al. J Orthop Res, 2014 Jan. PMID 24018537, Free PMC Article
    2. Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: a possible role in neuroprotection. Kwon KJ, et al. J Pineal Res, 2011 Mar. PMID 21073519
    3. Ubiquitination of mammalian Pex5p, the peroxisomal import receptor. Carvalho AF, et al. J Biol Chem, 2007 Oct 26. PMID 17726030
    4. Down-regulating protein kinase C alpha: functional cooperation between the proteasome and the endocytic system. Melnikov S, et al. Cell Signal, 2009 Nov. PMID 19586612
    5. Ubiquitin-dependent down-regulation of the neurokinin-1 receptor. Cottrell GS, et al. J Biol Chem, 2006 Sep 22. PMID 16849335

    See all (120) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polyubiquitin-C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399781.1 → NP_001386710.1  polyubiquitin-C isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q3ZBA1, Q63429
      Related
      ENSRNOP00000107356.1, ENSRNOT00000166204.1
      Conserved Domains (2) summary
      cd01803
      Location:77 → 152
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      cl28922
      Location:913 → 941
      Ubl1_cv_Nsp3_N-like; first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins

    2. NM_001399782.1 → NP_001386711.1  polyubiquitin-C isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q3ZBA1, Q63429
      UniProtKB/TrEMBL
      F1LML2

    3. NM_001399783.1 → NP_001386712.1  polyubiquitin-C isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q3ZBA1, Q63429
      UniProtKB/TrEMBL
      F1LML2

    4. NM_001399785.1 → NP_001386714.1  polyubiquitin-C isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q3ZBA1, Q63429
      Related
      ENSRNOP00000074688.3, ENSRNOT00000085692.3

    5. NM_001399786.1 → NP_001386715.1  polyubiquitin-C isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      Q5FWT0

    6. NM_001399787.1 → NP_001386716.1  polyubiquitin-C isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      Q5FWT0

    7. NM_001399788.1 → NP_001386717.1  polyubiquitin-C isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012

    8. NM_017314.3 → NP_059010.2  polyubiquitin-C isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q3ZBA1, Q63429

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      36899673..36905275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271601.1 → XP_063127671.1  polyubiquitin-C isoform X1

      UniProtKB/Swiss-Prot
      Q3ZBA1, Q63429

    2. XM_039089712.2 → XP_038945640.1  polyubiquitin-C isoform X1

      UniProtKB/Swiss-Prot
      Q3ZBA1, Q63429
      Conserved Domains (2) summary
      cd01803
      Location:77 → 152
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      cl28922
      Location:913 → 941
      Ubl1_cv_Nsp3_N-like; first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001399784.1: Suppressed sequence

      Description
      NM_001399784.1: This RefSeq was removed because it is redundant with another RefSeq (NM_017314.3).
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63429.1 GenPept UniProtKB/Swiss-Prot:Q63429

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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