Hs3st1 heparan sulfate-glucosamine 3-sulfotransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hs3st1provided by RGD
Official Full Name: heparan sulfate-glucosamine 3-sulfotransferase 1provided by RGD
Primary source: RGD:71084
See related: EnsemblRapid:ENSRNOG00000068537 AllianceGenome:RGD:71084
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 3OST-I
Summary: Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Predicted to be involved in glycosaminoglycan biosynthetic process and heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi lumen. Predicted to be active in Golgi apparatus. Orthologous to human HS3ST1 (heparan sulfate-glucosamine 3-sulfotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (75398101..75429628)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (71185826..71223263)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (75880410..75881346)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggested that HS3ST1 gene expression is strictly regulated by IL-4/IL-13.
Title: Direct effects of IL-4/IL-13 and the nematode Nippostrongylus brasiliensis on intestinal epithelial cells in vitro.

Submit: New GeneRIF Correction

General gene information

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Markers

Hs3st1 (e-PCR), detects polymorphism
- UniSTS:532545

AA963021 (e-PCR)
- UniSTS:247992

D5Wsu110e (e-PCR), detects polymorphism
- UniSTS:142564

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	IEA Inferred from Electronic Annotation more info
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	ISO Inferred from Sequence Orthology more info
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in glycosaminoglycan biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycosaminoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heparan sulfate proteoglycan biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in heparan sulfate proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi lumen	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heparan sulfate glucosamine 3-O-sulfotransferase 1

Names: heparan sulfate (glucosamine) 3-O-sulfotransferase 1; heparan sulfate 3-O-sulfotransferase 1; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1; heparan sulfate glucosamine 3-O-sulfotransferase I

NP_445843.2

EC 2.8.2.23

XP_038948434.1

EC 2.8.2.23

XP_063129752.1

EC 2.8.2.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053391.2 → NP_445843.2 heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A221CBA4, A6IJR8, G3V7E2

Conserved Domains (1) summary

pfam00685
Location:59 → 296

Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

75398101..75429628

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092506.2 → XP_038948434.1 heparan sulfate glucosamine 3-O-sulfotransferase 1 isoform X1

UniProtKB/TrEMBL

A0A221CBA4, A6IJR8, G3V7E2

Related

ENSRNOP00000094638.1, ENSRNOT00000105004.2

Conserved Domains (1) summary

pfam00685
Location:59 → 296

Sulfotransfer_1; Sulfotransferase domain
XM_063273682.1 → XP_063129752.1 heparan sulfate glucosamine 3-O-sulfotransferase 1 isoform X1

UniProtKB/TrEMBL

A0A221CBA4, A6IJR8, G3V7E2

Related

ENSRNOP00000091056.1, ENSRNOT00000098441.2