Kif3a kinesin family member 3a [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kif3aprovided by RGD
Official Full Name: kinesin family member 3aprovided by RGD
Primary source: RGD:621536
See related: EnsemblRapid:ENSRNOG00000007515 AllianceGenome:RGD:621536
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables kinesin binding activity. Involved in positive regulation of establishment or maintenance of cell polarity regulating cell shape; positive regulation of transport; and response to silicon dioxide. Located in neuronal cell body; plasma membrane bounded cell projection cytoplasm; and ribbon synapse. Biomarker of silicosis. Orthologous to human KIF3A (kinesin family member 3A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 192.1), Testes (RPKM 107.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (38226388..38263062)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (37725930..37761183)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (38918705..38953958)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

D10Rat168 (e-PCR), detects polymorphism
- UniSTS:226290

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables intraciliary transport particle B binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in alpha-tubulin acetylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
involved_in anterograde axonal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterograde dendritic transport	ISO Inferred from Sequence Orthology more info
involved_in anterograde dendritic transport of neurotransmitter receptor complex	ISO Inferred from Sequence Orthology more info
involved_in centriole-centriole cohesion	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cilium movement	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dentate gyrus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dorsal/ventral neural tube patterning	ISO Inferred from Sequence Orthology more info
involved_in dorsal/ventral neural tube patterning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dorsal/ventral pattern formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epidermal stem cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epidermis development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart looping	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in microtubule anchoring at centrosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within motile cilium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axo-dendritic protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of establishment or maintenance of cell polarity regulating cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to cell junction	ISO Inferred from Sequence Orthology more info
involved_in protein transport	ISO Inferred from Sequence Orthology more info
involved_in response to silicon dioxide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in smoothened signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cilium	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of kinesin II complex	ISO Inferred from Sequence Orthology more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in motile cilium	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor connecting cilium	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in ribbon synapse	IDA Inferred from Direct Assay more info	PubMed
located_in spindle microtubule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinesin-like protein KIF3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053377.1 → NP_445829.1 kinesin-like protein KIF3A

Status: VALIDATED

Source sequence(s)

AF155825, AW530197, CB616593, CR474808, CV116151

UniProtKB/TrEMBL

A0A0G2JUD6

Related

ENSRNOP00000009999.8, ENSRNOT00000009999.9

Conserved Domains (5) summary

cd01371
Location:13 → 345

KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

pfam00225
Location:20 → 345

Kinesin; Kinesin motor domain

pfam10473
Location:405 → 550

CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1

cd16269
Location:573 → 584

GBP_C; coiled coil [structural motif]

cl20817
Location:422 → 587

GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

38226388..38263062

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017597556.3 → XP_017453045.1 kinesin-like protein KIF3A isoform X2

UniProtKB/TrEMBL

A0A0G2JUD6
XM_063269988.1 → XP_063126058.1 kinesin-like protein KIF3A isoform X6

UniProtKB/TrEMBL

A0A0G2JUD6
XM_006246347.5 → XP_006246409.1 kinesin-like protein KIF3A isoform X1

UniProtKB/TrEMBL

A0A0G2JUD6, F1LQZ3

Conserved Domains (5) summary

cd01371
Location:13 → 345

KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

pfam00225
Location:20 → 345

Kinesin; Kinesin motor domain

pfam10473
Location:434 → 574

CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1

cd16269
Location:597 → 608

GBP_C; coiled coil [structural motif]

cl20817
Location:446 → 611

GBP_C; Guanylate-binding protein, C-terminal domain
XM_063269987.1 → XP_063126057.1 kinesin-like protein KIF3A isoform X4

UniProtKB/TrEMBL

A0A8I6AP89

Related

ENSRNOP00000096108.2, ENSRNOT00000111035.2
XM_017597557.3 → XP_017453046.1 kinesin-like protein KIF3A isoform X3

UniProtKB/TrEMBL

A0A0G2JUD6
XM_063269989.1 → XP_063126059.1 kinesin-like protein KIF3A isoform X7

UniProtKB/TrEMBL

A0A8I6AL48, A0A8I6AP89
XM_006246351.5 → XP_006246413.1 kinesin-like protein KIF3A isoform X5

See identical proteins and their annotated locations for XP_006246413.1

UniProtKB/TrEMBL

A0A0G2JUD6, A6HED3

Conserved Domains (4) summary

cd01371
Location:13 → 345

KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

pfam00225
Location:20 → 345

Kinesin; Kinesin motor domain

cd16269
Location:570 → 581

GBP_C; coiled coil [structural motif]

cl20817
Location:419 → 584

GBP_C; Guanylate-binding protein, C-terminal domain
XM_063269990.1 → XP_063126060.1 kinesin-like protein KIF3A isoform X10
XM_039086966.2 → XP_038942894.1 kinesin-like protein KIF3A isoform X8

Conserved Domains (1) summary

cd01371
Location:13 → 345

KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
XM_039086967.2 → XP_038942895.1 kinesin-like protein KIF3A isoform X9

Conserved Domains (1) summary

cd01371
Location:13 → 345

KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins