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    Catsperd cation channel sperm associated auxiliary subunit delta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680264, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Catsperdprovided by RGD
    Official Full Name
    cation channel sperm associated auxiliary subunit deltaprovided by RGD
    Primary source
    RGD:1594167
    See related
    EnsemblRapid:ENSRNOG00000048818 AllianceGenome:RGD:1594167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmem146
    Summary
    Predicted to be involved in flagellated sperm motility and sperm capacitation. Predicted to be located in cilium. Predicted to be part of CatSper complex. Predicted to be active in sperm principal piece. Orthologous to human CATSPERD (cation channel sperm associated auxiliary subunit delta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 51.9), Adrenal (RPKM 25.3) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Catsperd in Genome Data Viewer
    Location:
    9q11
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1546903..1585470)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1459967..1498342)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (10390307..10428666, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene mitochondrial contact site and cristae organizing system subunit 13 Neighboring gene ribosomal protein L36 Neighboring gene lon peptidase 1, mitochondrial Neighboring gene RAN binding protein 3 Neighboring gene calcyphosine Neighboring gene vimentin-type intermediate filament associated coiled-coil protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Chung JJ, et al. Nat Commun, 2011 Jan 11. PMID 21224844, Free PMC Article
    2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC189565

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sperm capacitation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm capacitation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm capacitation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of CatSper complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CatSper complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of CatSper complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of CatSper complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sperm principal piece IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm principal piece ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cation channel sperm-associated auxiliary subunit delta
    Names
    catSper-delta
    catSperdelta
    cation channel sperm-associated protein subunit delta
    catsper channel auxiliary subunit delta
    transmembrane protein 146

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134984.2 → NP_001128456.1  cation channel sperm-associated auxiliary subunit delta isoform 4 precursor

      See identical proteins and their annotated locations for NP_001128456.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AZN7
      Conserved Domains (1) summary
      pfam15020
      Location:37 → 697
      CATSPERD; Cation channel sperm-associated protein subunit delta

    2. NM_001433004.1 → NP_001419933.1  cation channel sperm-associated auxiliary subunit delta isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      A0A0H2UI41, B5DFM7
      UniProtKB/TrEMBL
      A0A8I6AZN7

    3. NM_001433008.1 → NP_001419937.1  cation channel sperm-associated auxiliary subunit delta isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AZN7

    4. NM_001433009.1 → NP_001419938.1  cation channel sperm-associated auxiliary subunit delta isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AZN7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      1546903..1585470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267717.1 → XP_063123787.1  cation channel sperm-associated auxiliary subunit delta isoform X16

    2. XM_008766772.4 → XP_008764994.1  cation channel sperm-associated auxiliary subunit delta isoform X15

      Conserved Domains (1) summary
      pfam15020
      Location:6 → 619
      CATSPERD; Cation channel sperm-associated protein subunit delta

    3. XM_039084200.2 → XP_038940128.1  cation channel sperm-associated auxiliary subunit delta isoform X12

      UniProtKB/TrEMBL
      A0A8I6AZN7
      Conserved Domains (1) summary
      pfam15020
      Location:1 → 677
      CATSPERD; Cation channel sperm-associated protein subunit delta

    4. XM_017596636.3 → XP_017452125.1  cation channel sperm-associated auxiliary subunit delta isoform X6

      UniProtKB/TrEMBL
      A0A8I6AZN7, A0A8L2QY57

    5. XM_017596639.3 → XP_017452128.1  cation channel sperm-associated auxiliary subunit delta isoform X10

      Related
      ENSRNOP00000094218.2, ENSRNOT00000094106.2

    6. XM_017596640.3 → XP_017452129.1  cation channel sperm-associated auxiliary subunit delta isoform X13

      UniProtKB/TrEMBL
      A0A8I6A393, A0A8I6AZN7
      Related
      ENSRNOP00000086900.1, ENSRNOT00000100019.2

    7. XM_063267709.1 → XP_063123779.1  cation channel sperm-associated auxiliary subunit delta isoform X2

    8. XM_006244340.4 → XP_006244402.1  cation channel sperm-associated auxiliary subunit delta isoform X3

      Conserved Domains (1) summary
      pfam15020
      Location:37 → 763
      CATSPERD; Cation channel sperm-associated protein subunit delta

    9. XM_017596637.3 → XP_017452126.1  cation channel sperm-associated auxiliary subunit delta isoform X9

      Related
      ENSRNOP00000067404.4, ENSRNOT00000071207.4

    10. XM_063267715.1 → XP_063123785.1  cation channel sperm-associated auxiliary subunit delta isoform X11

      UniProtKB/TrEMBL
      A0A8I6AZN7

    11. XM_063267720.1 → XP_063123790.1  cation channel sperm-associated auxiliary subunit delta isoform X17

    12. XM_063267711.1 → XP_063123781.1  cation channel sperm-associated auxiliary subunit delta isoform X5

      UniProtKB/TrEMBL
      A0A8I6AZN7

    13. XM_063267716.1 → XP_063123786.1  cation channel sperm-associated auxiliary subunit delta isoform X14

      UniProtKB/TrEMBL
      A0A8I6AZN7

    14. XM_063267714.1 → XP_063123784.1  cation channel sperm-associated auxiliary subunit delta isoform X8

      UniProtKB/TrEMBL
      A0A8I6AZN7

    15. XM_063267712.1 → XP_063123782.1  cation channel sperm-associated auxiliary subunit delta isoform X7

      UniProtKB/TrEMBL
      A0A8I6AZN7

    16. XM_063267708.1 → XP_063123778.1  cation channel sperm-associated auxiliary subunit delta isoform X1

    17. XM_063267710.1 → XP_063123780.1  cation channel sperm-associated auxiliary subunit delta isoform X4

    18. XM_063267718.1 → XP_063123788.1  cation channel sperm-associated auxiliary subunit delta isoform X16

    19. XM_063267721.1 → XP_063123791.1  cation channel sperm-associated auxiliary subunit delta isoform X18

      UniProtKB/TrEMBL
      A6KQW2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5DFM7.2 GenPept UniProtKB/Swiss-Prot:B5DFM7

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