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    Pcnp PEST proteolytic signal containing nuclear protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288165, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pcnpprovided by RGD
    Official Full Name
    PEST proteolytic signal containing nuclear proteinprovided by RGD
    Primary source
    RGD:1563775
    See related
    EnsemblRapid:ENSRNOG00000028411 AllianceGenome:RGD:1563775
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ab2-416
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be located in nuclear body. Predicted to be active in nucleus. Orthologous to human PCNP (PEST proteolytic signal containing nuclear protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 272.6), Lung (RPKM 254.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pcnp in Genome Data Viewer
    Location:
    11q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (58061885..58076436)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (44592766..44607372)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (47055641..47070319)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene SUMO specific peptidase 7 Neighboring gene uncharacterized LOC120095650 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene tRNA methyltransferase 10C, mitochondrial RNase P subunit Neighboring gene zinc finger and BTB domain containing 11 Neighboring gene small nucleolar RNA SNORA29 Neighboring gene G protein subunit gamma 5, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NIRF, a novel RING finger protein, is involved in cell-cycle regulation. Mori T, et al. Biochem Biophys Res Commun, 2002 Aug 23. PMID 12176013
    2. NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein. Mori T, et al. FEBS Lett, 2004 Jan 16. PMID 14741369
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    PEST proteolytic signal-containing nuclear protein
    Names
    PEST-containing nuclear protein
    liver regeneration-related protein LRRG084

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395615.1 → NP_001382544.1  PEST proteolytic signal-containing nuclear protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A0H2UHW4, A6IQQ1
      Conserved Domains (1) summary
      pfam15473
      Location:23 → 171
      PCNP; PEST, proteolytic signal-containing nuclear protein family

    2. NM_001395616.1 → NP_001382545.1  PEST proteolytic signal-containing nuclear protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A0H2UHW4, A0A8I5ZNV8
      Conserved Domains (1) summary
      pfam15473
      Location:23 → 170
      PCNP; PEST, proteolytic signal-containing nuclear protein family

    3. NM_001395617.1 → NP_001382546.1  PEST proteolytic signal-containing nuclear protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6IQQ2
      Conserved Domains (1) summary
      pfam15473
      Location:1 → 104
      PCNP; PEST, proteolytic signal-containing nuclear protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      58061885..58076436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270407.1 → XP_063126477.1  PEST proteolytic signal-containing nuclear protein isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHW4
      Related
      ENSRNOP00000039022.5, ENSRNOT00000039997.6

    2. XM_063270408.1 → XP_063126478.1  PEST proteolytic signal-containing nuclear protein isoform X2

      UniProtKB/Swiss-Prot
      Q7TP40
      UniProtKB/TrEMBL
      A0A0H2UHW4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001047846.1: Suppressed sequence

      Description
      NM_001047846.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TP40.1 GenPept UniProtKB/Swiss-Prot:Q7TP40

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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