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    Meaf6 MYST/Esa1-associated factor 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362594, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Meaf6provided by RGD
    Official Full Name
    MYST/Esa1-associated factor 6provided by RGD
    Primary source
    RGD:1310440
    See related
    EnsemblRapid:ENSRNOG00000009309 AllianceGenome:RGD:1310440
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310440
    Summary
    Predicted to contribute to histone acetyltransferase activity. Predicted to be involved in regulation of cell cycle; regulation of cell growth; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in kinetochore; nucleolus; and nucleoplasm. Predicted to be part of MOZ/MORF histone acetyltransferase complex; NuA4 histone acetyltransferase complex; and nucleosome. Orthologous to human MEAF6 (MYST/Esa1 associated factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 78.9), Testes (RPKM 61.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Meaf6 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (142628281..142653076)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (137344681..137369703)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (143081298..143103225)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene G protein nucleolar 2 Neighboring gene dynein, axonemal, light intermediate chain 1 Neighboring gene Smad nuclear interacting protein 1 Neighboring gene zinc finger CCCH type containing 12A Neighboring gene transfer RNA proline (anticodon AGG) 51

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Ullah M, et al. Mol Cell Biol, 2008 Nov. PMID 18794358, Free PMC Article
    2. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21502417
    3. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Ohta S, et al. Cell, 2010 Sep 3. PMID 20813266, Free PMC Article
    4. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Doyon Y, et al. Mol Cell Biol, 2004 Mar. PMID 14966270, Free PMC Article
    5. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Doyon Y, et al. Mol Cell, 2006 Jan 6. PMID 16387653

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to histone H3K14 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to histone H4K12 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to histone H4K5 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to histone H4K8 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    chromatin modification-related protein MEAF6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113784.2 → NP_001107256.1  chromatin modification-related protein MEAF6 isoform 1

      See identical proteins and their annotated locations for NP_001107256.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IS74, B0BNB4
      Related
      ENSRNOP00000109927.1, ENSRNOT00000145833.1
      Conserved Domains (1) summary
      pfam09340
      Location:18 → 96
      NuA4; Histone acetyltransferase subunit NuA4

    2. NM_001429180.1 → NP_001416109.1  chromatin modification-related protein MEAF6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IS74

    3. NM_001429181.1 → NP_001416110.1  chromatin modification-related protein MEAF6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IS74

    RNA

    1. NR_190677.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    2. NR_190678.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    3. NR_190679.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    4. NR_190680.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      142628281..142653076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238886.5 → XP_006238948.3  chromatin modification-related protein MEAF6 isoform X1

      Related
      ENSRNOP00000086381.2, ENSRNOT00000119468.2

    2. XM_006238887.5 → XP_006238949.3  chromatin modification-related protein MEAF6 isoform X2

      Related
      ENSRNOP00000076844.1, ENSRNOT00000109282.2

    RNA

    1. XR_005504489.2 RNA Sequence

    2. XR_592701.4 RNA Sequence

    3. XR_354271.5 RNA Sequence

    4. XR_010066423.1 RNA Sequence

    5. XR_354272.5 RNA Sequence

      Related
      ENSRNOT00000094438.2

    6. XR_354273.5 RNA Sequence

      Related
      ENSRNOT00000067204.4
    Nucleotide Protein Strain
    Heading Accession and Version

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