Hdac8 histone deacetylase 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Hdac8provided by RGD
Full Name: histone deacetylase 8provided by RGD
Primary source: RGD:1562895
See related: EnsemblRapid:ENSRNOG00000003122 AllianceGenome:RGD:1562895
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: HD8; RGD1562895
Summary: Enables chromatin binding activity and deacetylase activity. Involved in several processes, including cellular response to forskolin; cellular response to trichostatin A; and negative regulation of macromolecule metabolic process. Predicted to be located in chromosome and cytoplasm. Predicted to be active in nucleus. Biomarker of amphetamine abuse; hypertension; and renovascular hypertension. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 26.7), Brain (RPKM 23.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (71425240..71632865, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (67385288..67593014, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (72163777..72370058, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that HDAC4 and HDAC8 may serve as key upstream mediators of MAPK in regulating the IL1betainduced cartilage catabolic and degradation.
Title: Histone deacetylase-4 and histone deacetylase-8 regulate interleukin-1β-induced cartilage catabolic degradation through MAPK/JNK and ERK pathways.

Submit: New GeneRIF Correction

General gene information

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Markers

RH131931 (e-PCR)
- UniSTS:215214

AA850209 (e-PCR)
- UniSTS:250288

BE121059 (e-PCR)
- UniSTS:248007

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables Hsp90 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K14 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H3K4 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H3K9 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K12 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K16 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K5 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K8 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity	ISO Inferred from Sequence Orthology more info
enables histone deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone decrotonylase activity	IEA Inferred from Electronic Annotation more info
enables histone decrotonylase activity	ISO Inferred from Sequence Orthology more info
enables histone decrotonylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein lysine deacetylase activity	ISO Inferred from Sequence Orthology more info
enables tubulin deacetylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to forskolin	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to trichostatin A	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic sister chromatid cohesion	IEA Inferred from Electronic Annotation more info
involved_in mitotic sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid cohesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein modification process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of telomere maintenance	IEA Inferred from Electronic Annotation more info
involved_in regulation of telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in response to 11-deoxycorticosterone	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone deacetylase 8

Names: protein deacetylase HDAC8; protein decrotonylase HDAC8

NP_001119845.2

EC 3.5.1.98

XP_017457598.1

EC 3.5.1.98

XP_038955828.1

EC 3.5.1.98

XP_063136216.1

EC 3.5.1.98

XP_063136217.1

EC 3.5.1.98

XP_063136218.1

EC 3.5.1.98

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126373.2 → NP_001119845.2 histone deacetylase 8

See identical proteins and their annotated locations for NP_001119845.2

Status: VALIDATED

Source sequence(s)

BC162023, FM086081

UniProtKB/Swiss-Prot

B1WC68

UniProtKB/TrEMBL

A0A8I6GB67

Related

ENSRNOP00000004224.4, ENSRNOT00000004224.8

Conserved Domains (1) summary

cd10000
Location:16 → 377

HDAC8; Histone deacetylase 8 (HDAC8)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

71425240..71632865 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063280147.1 → XP_063136217.1 histone deacetylase 8 isoform X3

UniProtKB/TrEMBL

A0A8I5ZP78
XM_017602109.3 → XP_017457598.1 histone deacetylase 8 isoform X1

UniProtKB/TrEMBL

A0A8I5ZP78
XM_063280146.1 → XP_063136216.1 histone deacetylase 8 isoform X2

UniProtKB/TrEMBL

A0A8I5ZP78
XM_039099900.2 → XP_038955828.1 histone deacetylase 8 isoform X4

UniProtKB/TrEMBL

A6IQE7

Conserved Domains (1) summary

cl17011
Location:16 → 246

Arginase_HDAC; Arginase-like and histone-like hydrolases
XM_063280148.1 → XP_063136218.1 histone deacetylase 8 isoform X5