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    Rnf152 ring finger protein 152 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293561, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf152provided by RGD
    Official Full Name
    ring finger protein 152provided by RGD
    Primary source
    RGD:1305251
    See related
    EnsemblRapid:ENSRNOG00000014859 AllianceGenome:RGD:1305251
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable small GTPase binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; negative regulation of TORC1 signaling; and protein ubiquitination. Predicted to be located in lysosome and organelle membrane. Predicted to be active in lysosomal membrane. Orthologous to human RNF152 (ring finger protein 152). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 175.4), Brain (RPKM 56.1) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnf152 in Genome Data Viewer
    Location:
    13p11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (21838634..21918000, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (21324039..21403405, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (25183295..25262785, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene high mobility group box 3, pseudogene 2 Neighboring gene cadherin 20 Neighboring gene uncharacterized LOC102547165 Neighboring gene uncharacterized LOC134481471 Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities. Zhang S, et al. Protein Cell, 2010 Jul. PMID 21203937, Free PMC Article
    2. The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation. Deng L, et al. Mol Cell, 2015 Jun 4. PMID 25936802
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to amino acid starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein monoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF152
    Names
    RING-type E3 ubiquitin transferase RNF152
    NP_001099775.1
    XP_017454255.1
    XP_017454256.1
    XP_017454257.1
    XP_017454258.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106305.3 → NP_001099775.1  E3 ubiquitin-protein ligase RNF152

      See identical proteins and their annotated locations for NP_001099775.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      D4A723
      Conserved Domains (1) summary
      cd16548
      Location:11 → 55
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

    2. NM_001429979.1 → NP_001416908.1  E3 ubiquitin-protein ligase RNF152

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      D4A723

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      21838634..21918000 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598769.3 → XP_017454258.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      D4A723
      Related
      ENSRNOP00000095982.1, ENSRNOT00000107961.2
      Conserved Domains (1) summary
      cd16548
      Location:11 → 55
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

    2. XM_017598766.3 → XP_017454255.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      Related
      ENSRNOP00000097172.1, ENSRNOT00000105662.2
      Conserved Domains (1) summary
      cd16548
      Location:11 → 55
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

    3. XM_017598768.3 → XP_017454257.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      D4A723
      Conserved Domains (1) summary
      cd16548
      Location:11 → 55
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

    4. XM_017598767.3 → XP_017454256.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      D4A723
      Related
      ENSRNOP00000093936.1, ENSRNOT00000102604.2
      Conserved Domains (1) summary
      cd16548
      Location:11 → 55
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4A723.1 GenPept UniProtKB/Swiss-Prot:D4A723

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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