Myo1g myosin IG [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myo1gprovided by RGD
Official Full Name: myosin IGprovided by RGD
Primary source: RGD:1306016
See related: EnsemblRapid:ENSRNOG00000059140 AllianceGenome:RGD:1306016
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in Fc-gamma receptor signaling pathway involved in phagocytosis and T cell mediated immunity. Predicted to act upstream of or within several processes, including T cell meandering migration; cell gliding; and phagocytosis. Predicted to be located in several cellular components, including lamellipodium; microvillus; and phagocytic cup. Predicted to be part of myosin complex. Orthologous to human MYO1G (myosin IG). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 241.4), Thymus (RPKM 220.2) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (85600619..85615760, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (81386701..81401843, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (86781243..86796393, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

MARC_4333-4334:996679561:1 (e-PCR)
- UniSTS:269357

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell meandering migration	ISO Inferred from Sequence Orthology more info
involved_in T cell mediated immunity	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell gliding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in leading edge membrane	ISO Inferred from Sequence Orthology more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in phagocytic cup	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: unconventional myosin-Ig

Names: myosin-Ig

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134843.1 → NP_001128315.1 unconventional myosin-Ig

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A6IKU7

Conserved Domains (3) summary

smart00242
Location:4 → 703

MYSc; Myosin. Large ATPases

cd01378
Location:23 → 691

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:812 → 1002

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

85600619..85615760 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006251218.5 → XP_006251280.1 unconventional myosin-Ig isoform X1

UniProtKB/TrEMBL

A0A0G2K6E3, A6IKU7

Related

ENSRNOP00000073777.1, ENSRNOT00000092021.3

Conserved Domains (3) summary

smart00242
Location:4 → 706

MYSc; Myosin. Large ATPases

cd01378
Location:23 → 694

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:815 → 1005

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_006251221.5 → XP_006251283.1 unconventional myosin-Ig isoform X2

See identical proteins and their annotated locations for XP_006251283.1

Conserved Domains (2) summary

cl22853
Location:49 → 496

Motor_domain; Myosin and Kinesin motor domain

pfam06017
Location:617 → 807

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_006251223.4 → XP_006251285.1 unconventional myosin-Ig isoform X2

See identical proteins and their annotated locations for XP_006251285.1

Conserved Domains (2) summary

cl22853
Location:49 → 496

Motor_domain; Myosin and Kinesin motor domain

pfam06017
Location:617 → 807

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001009634.1: Suppressed sequence

Description

NM_001009634.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.