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    Notum NOTUM, palmitoleoyl-protein carboxylesterase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303743, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Notumprovided by RGD
    Official Full Name
    NOTUM, palmitoleoyl-protein carboxylesteraseprovided by RGD
    Primary source
    RGD:1307119
    See related
    EnsemblRapid:ENSRNOG00000036680 AllianceGenome:RGD:1307119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307119
    Summary
    Predicted to enable lipase activity and palmitoleyl hydrolase activity. Acts upstream of or within bone development. Predicted to be located in extracellular region. Orthologous to human NOTUM (notum, palmitoleoyl-protein carboxylesterase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 96.2), Thymus (RPKM 23.3) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Notum in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106431572..106438654, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105933245..105940327, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109832977..109840661, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene MAF bZIP transcription factor G Neighboring gene pyrroline-5-carboxylate reductase 1 Neighboring gene myeloid-associated differentiation marker-like 2 Neighboring gene ASPSCR1 tether for SLC2A4, UBX domain containing Neighboring gene centromere protein X

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF. Torisu Y, et al. Cancer Sci, 2008 Jun. PMID 18429952, Free PMC Article
    2. NOTUM inhibition increases endocortical bone formation and bone strength. Brommage R, et al. Bone Res, 2019. PMID 30622831, Free PMC Article
    3. Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation. Zhang X, et al. Dev Cell, 2015 Mar 23. PMID 25771893, Free PMC Article
    4. Notum deacylates Wnt proteins to suppress signalling activity. Kakugawa S, et al. Nature, 2015 Mar 12. PMID 25731175, Free PMC Article
    5. Gene expression profile of the rat eye iridocorneal angle: NEIBank expressed sequence tag analysis. Ahmed F, et al. Invest Ophthalmol Vis Sci, 2004 Sep. PMID 15326124

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Describes the human ortholog, and characterizes the mouse and human promoters.
      Title: Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC109547

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables palmitoleyl hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoleyl hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within bone development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within bone development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein depalmitoleylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoleoyl-protein carboxylesterase NOTUM
    NP_001013997.2
    NP_001402706.1
    XP_006247949.1
    XP_006247950.1
    XP_038942152.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013975.3 → NP_001013997.2  palmitoleoyl-protein carboxylesterase NOTUM precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D3ZXI3
      Related
      ENSRNOP00000051830.2, ENSRNOT00000054947.4
      Conserved Domains (1) summary
      pfam03283
      Location:88 → 426
      PAE; Pectinacetylesterase

    2. NM_001415777.1 → NP_001402706.1  palmitoleoyl-protein carboxylesterase NOTUM precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D3ZXI3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      106431572..106438654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247887.5 → XP_006247949.1  palmitoleoyl-protein carboxylesterase NOTUM isoform X1

      See identical proteins and their annotated locations for XP_006247949.1

      UniProtKB/TrEMBL
      A6HLH5
      Related
      ENSRNOP00000111783.1, ENSRNOT00000125509.1
      Conserved Domains (1) summary
      pfam03283
      Location:124 → 459
      PAE; Pectinacetylesterase

    2. XM_006247888.5 → XP_006247950.1  palmitoleoyl-protein carboxylesterase NOTUM isoform X2

      Conserved Domains (1) summary
      pfam03283
      Location:50 → 358
      PAE; Pectinacetylesterase

    3. XM_039086224.2 → XP_038942152.1  palmitoleoyl-protein carboxylesterase NOTUM isoform X3

      Conserved Domains (1) summary
      pfam03283
      Location:123 → 277
      PAE; Pectinacetylesterase
    Nucleotide Protein Strain
    Heading Accession and Version

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