Amigo3 adhesion molecule with Ig like domain 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Amigo3provided by RGD
Official Full Name: adhesion molecule with Ig like domain 3provided by RGD
Primary source: RGD:631413
See related: EnsemblRapid:ENSRNOG00000064183 AllianceGenome:RGD:631413
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; negative regulation of neuron projection development; and nervous system development. Predicted to be active in membrane. Biomarker of sciatic neuropathy. Orthologous to human AMIGO3 (adhesion molecule with Ig like domain 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (117620499..117622025)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (108741899..108743425)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (116830773..116832299)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

BE119447 (e-PCR)
- UniSTS:249191

Amigo3 (e-PCR), detects polymorphism
- UniSTS:525536

RH139593 (e-PCR)
- UniSTS:221677

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: amphoterin-induced protein 3

Names: AMIGO-3; alivin-3; amphoterin induced gene and ORF 3; transmembrane protein AMIGO3

NP_835280.1

EC 2.7.7.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178144.1 → NP_835280.1 amphoterin-induced protein 3 precursor

See identical proteins and their annotated locations for NP_835280.1

Status: PROVISIONAL

Source sequence(s)

AY237731

UniProtKB/Swiss-Prot

Q80ZD5

UniProtKB/TrEMBL

A6I331

Related

ENSRNOP00000081738.1, ENSRNOT00000118165.2

Conserved Domains (4) summary

sd00033
Location:65 → 86

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:65 → 121

LRR_8; Leucine rich repeat

pfam13927
Location:279 → 355

Ig_3; Immunoglobulin domain

cd00096
Location:295 → 303

Ig; Ig strand B [structural motif]