Stt3a STT3 oligosaccharyltransferase complex catalytic subunit A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stt3aprovided by RGD
Official Full Name: STT3 oligosaccharyltransferase complex catalytic subunit Aprovided by RGD
Primary source: RGD:1565793
See related: EnsemblRapid:ENSRNOG00000031896 AllianceGenome:RGD:1565793
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Itm1; RGD1565793
Summary: Predicted to enable dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in co-translational protein modification and protein N-linked glycosylation via asparagine. Predicted to be located in membrane. Predicted to be part of oligosaccharyltransferase complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iw. Orthologous to human STT3A (STT3 oligosaccharyltransferase complex catalytic subunit A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 283.6), Kidney (RPKM 231.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (44632473..44671960, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (36443623..36483111, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (39204218..39243751, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8Got43 (e-PCR)
- UniSTS:113670

BE105951 (e-PCR)
- UniSTS:261554

RH143132 (e-PCR)
- UniSTS:232379

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in co-translational protein modification	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation via asparagine	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of oligosaccharyltransferase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

Names: STT3, subunit of the oligosaccharyltransferase complex, homolog A; STT3A, catalytic subunit of the oligosaccharyltransferase complex; STT3A, subunit of the oligosaccharyltransferase complex (catalytic); integral membrane protein 1; integral transmembrane protein 1

NP_001128221.1

EC 2.4.99.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.