Cdh7 cadherin 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdh7provided by RGD
Official Full Name: cadherin 7provided by RGD
Primary source: RGD:1306856
See related: EnsemblRapid:ENSRNOG00000032490 AllianceGenome:RGD:1306856
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cad7
Summary: Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and cell-cell junction organization. Predicted to be located in plasma membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Orthologous to human CDH7 (cadherin 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 134.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 13q11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (27186223..27336076)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (26672058..26821571)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (31081064..31228884)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of cad7 and cad20 demarcates the compartments, boundaries, progenitor domains, specific nuclei and specific neural circuits during mammalian brain development.
Title: Expression study of cadherin7 and cadherin20 in the embryonic and adult rat central nervous system.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cadherin-7

Names: Cadherin7; cadherin 7, type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012737.2 → NP_001012755.2 cadherin-7 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q5DWV2

UniProtKB/TrEMBL

A6JSW4, G3V9J2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

27186223..27336076

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017598763.3 → XP_017454252.1 cadherin-7 isoform X1

Related

ENSRNOP00000049491.2, ENSRNOT00000041413.5

Conserved Domains (3) summary

cd11304
Location:157 → 258

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:73 → 151

CA; Cadherin repeats

pfam01049
Location:639 → 777

Cadherin_C; Cadherin cytoplasmic region
XM_017598764.3 → XP_017454253.1 cadherin-7 isoform X1

UniProtKB/Swiss-Prot

Q5DWV2

UniProtKB/TrEMBL

A6JSW4, G3V9J2

Conserved Domains (3) summary

cd11304
Location:157 → 258

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:73 → 151

CA; Cadherin repeats

pfam01049
Location:639 → 777

Cadherin_C; Cadherin cytoplasmic region