Acp5 acid phosphatase 5, tartrate resistant [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acp5provided by RGD
Official Full Name: acid phosphatase 5, tartrate resistantprovided by RGD
Primary source: RGD:2022
See related: EnsemblRapid:ENSRNOG00000046261 AllianceGenome:RGD:2022
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Trap; TTRRAP
Summary: Enables acid phosphatase activity. Involved in several processes, including bone resorption; cellular response to zinc ion starvation; and response to L-ascorbic acid. Located in extracellular space. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia. Orthologous to human ACP5 (acid phosphatase 5, tartrate resistant). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 417.2), Kidney (RPKM 210.0) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (28939984..28946639, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (20663984..20670604, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (23142733..23149067, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RANKL and OPG expressions were not changed by chronic exposure to fluoride in the drinking water during the studied periods; on the other hand, TRAP expression was changed (at 7 days) by chronic exposure to fluoride
Title: Effects of fluoride in bone repair: an evaluation of RANKL, OPG and TRAP expression.
increased osteoclast activity does not affect TRAP expression in osteoblasts and osteocytes
Title: Increased tartrate-resistant Acid phosphatase expression in osteoblasts and osteocytes in experimental osteoporosis in rats.
Polyphosphate may play an important regulatory role in osteoclastic bone resorption by inhibiting TRAP activity.
Title: Polyphosphate-mediated inhibition of tartrate-resistant acid phosphatase and suppression of bone resorption of osteoclasts.
Data indicate that tartrate-resistant acid phosphatase 5b levels treated with cadmium and fluoride or in combination were 1-2.5 folds higher than the control.
Title: Effects of fluoride and cadmium co-exposure on bone in male rats.
induction of TRAP provides an early sign of macrophage responsiveness in DSS induced colitis
Title: Induction and cellular expression of tartrate resistant acid phosphatase during dextran sodium sulphate induced colitis in rats.
This study demonstrates that adhesion of isolated neonatal rat osteoclasts in vitro was augmented on bovine milk osteopontin (bmOPN) with post-translational modifications (PTMs) compared to human Escherichia-coli-derived recombinant OPN without PTMs.
Title: Osteoclast migration on phosphorylated osteopontin is regulated by endogenous tartrate-resistant acid phosphatase.
insulin-dependent diabetes mellitus contributes to bone loss through changes in gene expression of TRAP and cathepsin K in osteoclasts as well as osteocalcin in osteoblasts
Title: Increased cathepsin K and tartrate-resistant acid phosphatase expression in bone of streptozotocin-induced diabetic rats.
TRAP enzyme has a rapid turnover in osteoclasts and uses a transcytotic pathway
Title: The effects of colony-stimulating factor-1 (CSF-1) on the development of osteoclasts and their expression of tartrate-resistant acid phosphatase (TRAP) in toothless (tl-osteopetrotic) rats.
Cathepsin K co-localized with TRAP in osteoclast-resorptive compartments, supporting a role for cathepsin K in the extracellular processing of monomeric TRAP in the resorption lacuna.
Title: Proteolytic excision of a repressive loop domain in tartrate-resistant acid phosphatase by cathepsin K in osteoclasts.
The co-localization of PAP/TRAP and the cysteine protease cathepsin L could suggest a role for cathepsin L in the in vivo proteolytic processing of PAP/TRAP. proteolytic processing of PAP/TRAP
Title: Differential expression of monomeric and proteolytically processed forms of tartrate-resistant acid phosphatase in rat tissues.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

RH133500 (e-PCR)
- UniSTS:216783

RH94519 (e-PCR)
- UniSTS:119767

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acid phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acid phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables acid phosphatase activity	IEA Inferred from Electronic Annotation more info
enables acid phosphatase activity	ISO Inferred from Sequence Orthology more info
enables acid phosphatase activity	TAS Traceable Author Statement more info	PubMed
enables ferric iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferric iron binding	ISO Inferred from Sequence Orthology more info
enables ferric iron binding	ISS Inferred from Sequence or Structural Similarity more info
enables ferrous iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferrous iron binding	ISO Inferred from Sequence Orthology more info
enables ferrous iron binding	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bone morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in bone resorption	IBA Inferred from Biological aspect of Ancestor more info
involved_in bone resorption	IEA Inferred from Electronic Annotation more info
involved_in bone resorption	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within bone resorption	ISO Inferred from Sequence Orthology more info
involved_in bone resorption	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to zinc ion starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in defense response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal response to stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-12 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage cytokine production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of superoxide anion generation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in ossification	IEP Inferred from Expression Pattern more info	PubMed
involved_in osteoclast differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to L-ascorbic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cholesterol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cytokine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cytokine	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to macrophage colony-stimulating factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in superoxide anion generation	IEA Inferred from Electronic Annotation more info
acts_upstream_of superoxide anion generation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tartrate-resistant acid phosphatase type 5

Names: TR-AP; acid phosphatase type V; tartrate-resistant acid ATPase; trATPase; type 5 acid phosphatase

NP_001257818.1

EC 3.1.3.2

NP_062017.2

EC 3.1.3.2

XP_006242754.1

EC 3.1.3.2

XP_006242755.1

EC 3.1.3.2

XP_006242756.1

EC 3.1.3.2

XP_017450976.1

EC 3.1.3.2

XP_063121053.1

EC 3.1.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270889.1 → NP_001257818.1 tartrate-resistant acid phosphatase type 5 isoform 2 precursor

See identical proteins and their annotated locations for NP_001257818.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' exon, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

BC078847, BM386942

UniProtKB/Swiss-Prot

P29288

UniProtKB/TrEMBL

A0A8L2QYB7, A6JNZ2

Conserved Domains (1) summary

cd07378
Location:28 → 313

MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
NM_019144.2 → NP_062017.2 tartrate-resistant acid phosphatase type 5 isoform 1 precursor

See identical proteins and their annotated locations for NP_062017.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

BC078847, BM386942, CV074238

UniProtKB/TrEMBL

A0A0G2K6Z6, A0A8L2QYB7, A6JNZ1

Related

ENSRNOP00000074001.1, ENSRNOT00000092200.3

Conserved Domains (2) summary

cd07378
Location:36 → 321

MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

pfam00149
Location:36 → 252

Metallophos; Calcineurin-like phosphoesterase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

28939984..28946639 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017595487.3 → XP_017450976.1 tartrate-resistant acid phosphatase type 5 isoform X1

UniProtKB/TrEMBL

A0A0G2K6Z6, A0A8L2QYB7, A6JNZ1

Conserved Domains (2) summary

cd07378
Location:36 → 321

MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

pfam00149
Location:36 → 252

Metallophos; Calcineurin-like phosphoesterase
XM_006242693.5 → XP_006242755.1 tartrate-resistant acid phosphatase type 5 isoform X2

See identical proteins and their annotated locations for XP_006242755.1

UniProtKB/Swiss-Prot

P29288

UniProtKB/TrEMBL

A0A8L2QYB7, A6JNZ2

Conserved Domains (1) summary

cd07378
Location:28 → 313

MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
XM_063264983.1 → XP_063121053.1 tartrate-resistant acid phosphatase type 5 isoform X1

UniProtKB/TrEMBL

A0A0G2K6Z6, A0A8L2QYB7, A6JNZ1
XM_006242692.5 → XP_006242754.1 tartrate-resistant acid phosphatase type 5 isoform X2

See identical proteins and their annotated locations for XP_006242754.1

UniProtKB/Swiss-Prot

P29288

UniProtKB/TrEMBL

A0A8L2QYB7, A6JNZ2

Conserved Domains (1) summary

cd07378
Location:28 → 313

MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
XM_006242694.3 → XP_006242756.1 tartrate-resistant acid phosphatase type 5 isoform X2

See identical proteins and their annotated locations for XP_006242756.1

UniProtKB/Swiss-Prot

P29288

UniProtKB/TrEMBL

A0A8L2QYB7, A6JNZ2

Related

ENSRNOP00000066364.3, ENSRNOT00000075237.4

Conserved Domains (1) summary

cd07378
Location:28 → 313

MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain